Expression of Cyclin D1 and Its Relationship to Hormone Receptors and Survival in Breast Cancer

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dc.contributor.authorYeniay, Levent
dc.contributor.authorDemir, Derya
dc.contributor.authorAydın, Barbaros
dc.contributor.authorZekioğlu, Osman
dc.contributor.authorÖzdemir, Necmettin
dc.contributor.authorKitapçıoğlu, Gül
dc.contributor.authorAlanyalı, Senem
dc.date.accessioned2020-12-01T12:29:25Z
dc.date.available2020-12-01T12:29:25Z
dc.date.issued2017
dc.departmentEge Üniversitesien_US
dc.description.abstractThe aim of the present study was to evaluate rate of cyclin D1 expression and examine its relationship to clinicopathological factors and impact on prognosis in breast cancer patients.METHODSTotal of 85 estrogen receptor (ER)-positive breast cancer patients were included. Expression of cyclin D1, ER, progesterone receptor (PR), and Ki-67 were determined using immunohistochemistry evaluation.RESULTSPatients’ median age was 49 years (range: 27–83 years) and cyclin D1 was positive in 90.5% of the patients. Cyclin D1 expression was positively correlated with rate of ER positivity and Ki-67 expression (r=0.4; p<0.0001 and r=0.3; p=0.001, respectively). Five-year disease-free and overall survival (OS) rates were not different between patients with or without cyclin D1 expression (81% vs 79% and 93% vs 87%; p=0.8 and 0.4, respectively). High modified Bloom-Richardson grade (p=0.04), high nuclear grade (p=0.021), and PR negativity (p=0.011) were found to be poor prognostic factors for OS rate in univariate analysis.CONCLUSIONIn this study, cyclin D1 was not found to be prognostic factor; however, it is correlated with ER positivity and Ki-67 expression in breast cancer patientsen_US
dc.identifier.endpage13en_US
dc.identifier.issn1300-7467
dc.identifier.issue1en_US
dc.identifier.startpage7en_US
dc.identifier.urihttps://app.trdizin.gov.tr//makale/TWpnek5qWXlNZz09
dc.identifier.urihttps://hdl.handle.net/11454/65912
dc.identifier.volume32en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofTürk Onkoloji Dergisien_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectOnkolojien_US
dc.titleExpression of Cyclin D1 and Its Relationship to Hormone Receptors and Survival in Breast Canceren_US
dc.typeArticleen_US

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