The effect of hematopoietic progenitor cells' temperature on cardiac arrhythmias in patients given peripheral blood progenitor cells

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dc.contributor.authorDonmez, Ayhan
dc.contributor.authorZoghi, Mehdi
dc.contributor.authorCagirgan, Seckin
dc.contributor.authorAcarlar, Ceylan
dc.contributor.authorTombuloglu, Murat
dc.date.accessioned2019-10-27T19:18:32Z
dc.date.available2019-10-27T19:18:32Z
dc.date.issued2006
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground: Infusion of cryopreserved and non-cryopreserved hematopoietic progenitor cells (HPC) is associated with a broad variety of symptoms. In this study, we have investigated infusion-related toxicity regarding temperature of cryopreserved autologous peripheral blood progenitor cells (PBPCs) transplanted in 31 and allogeneic non-cryopreserved PBPCs in 4 patients receiving high dose chemotherapy and stem cells transplantation for hematological malignancies. Study design and method: A 24 h ECG-Holter recording system was used to obtain cardiac arrhythmias. Two milliliters HPC were collected from entrance site of venous access to evaluate the temperature of infused HPC. Results: We have detected arrhythmias in 17 (48.58%) of our patients before, during and after infusion. Median temperature of the infusat was 21 degrees C (18-28.2). Arrhythmias during infusion were detected in 8 (22.85%) patients. The temperatures of infused HPCs were not statistically different in group with and without arrhythmias as 22 degrees C and 21 degrees C, respectively (P > 0.05). And also, volume, contents [dimethylsulphoxide (DMSO), red blood cells (RBC), platelet (PLT), and total nucleated cell (TNQ)] of product, and rate of infusion speed did not have any effect on arrhythmias. Conclusion: As a result of this study, we have concluded that the temperature of HPC does not cause any systemic hypothermia and does not have any relation to arrhythmias detected during infusion. (c) 2006 Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.transci.2005.12.007en_US
dc.identifier.endpage251en_US
dc.identifier.issn1473-0502
dc.identifier.issue3en_US
dc.identifier.pmid16931400en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage245en_US
dc.identifier.urihttps://doi.org/10.1016/j.transci.2005.12.007
dc.identifier.urihttps://hdl.handle.net/11454/38607
dc.identifier.volume34en_US
dc.identifier.wosWOS:000240580100004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofTransfusion and Apheresis Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjecttemperatureen_US
dc.subjectprogenitor cellsen_US
dc.subjectarrhythmiasen_US
dc.titleThe effect of hematopoietic progenitor cells' temperature on cardiac arrhythmias in patients given peripheral blood progenitor cellsen_US
dc.typeArticleen_US

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