Effects of Saccharomyces boulardii in children with acute diarrhoea

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dc.contributor.authorKurugöl Z.
dc.contributor.authorKoturoglu G.
dc.date.accessioned2019-10-27T00:11:48Z
dc.date.available2019-10-27T00:11:48Z
dc.date.issued2005
dc.departmentEge Üniversitesien_US
dc.description.abstractAim: Certain probiotic agents, e.g. Lactobacillus GG, have shown efficacy in clinical trials for the treatment of acute childhood diarrhoea, but few studies have examined the effect of Saccharomyces boulardii. We evaluated the effect of S. boulardii in children with acute diarrhoea. Methods: Two hundred children were randomized to receive S. boulardii in a granulated form in a daily dose of 250 mg (S. boulardii group) or placebo (placebo group) for 5 d. Clinical and demographic characteristics on admission were similar between the study groups. Results: The medians of the average stool frequency after the second day of the treatment were significantly lower in the S. boulardii group than in the placebo group (p = 0.003). The duration of diarrhoea significantly reduced in the S. boulardii group compared with the placebo group (4.7 vs 5.5 d, p = 0.03). The effect of S. boulardii on watery diarrhoea became apparent after the second day of the treatment. The duration of hospital stay was shorter in the S. boulardii group than in the placebo group (2.9 vs 3.9 d, p < 0.001). Four children from the placebo group versus only one child from the S. boulardii group had persisting diarrhoea. Conclusion: The placebo-controlled study suggested that S. boulardii significantly reduced the duration of acute diarrhoea and the duration of hospital stay. S. boulardii seems to be a promising agent for the amelioration of the course of acute diarrhoea in children when used therapeutically.en_US
dc.identifier.doi10.1080/08035250410022521en_US
dc.identifier.endpage47en_US
dc.identifier.issn0803-5253
dc.identifier.issue1en_US
dc.identifier.pmid15858959en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage44en_US
dc.identifier.urihttps://doi.org/10.1080/08035250410022521
dc.identifier.urihttps://hdl.handle.net/11454/22238
dc.identifier.volume94en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofActa Paediatrica, International Journal of Paediatricsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChildhood diarrhoeaen_US
dc.subjectProbioticsen_US
dc.subjectSaccharomyces boulardiien_US
dc.titleEffects of Saccharomyces boulardii in children with acute diarrhoeaen_US
dc.typeArticleen_US

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