Whole-genome analysis illustrates global clonal population structure of the ubiquitous dermatophyte pathogen trichophyton rubrum

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dc.contributor.authorPersinoti G.F.
dc.contributor.authorMartinez D.A.
dc.contributor.authorLi W.
dc.contributor.authorDöğen A.
dc.contributor.authorBillmyre R.B.
dc.contributor.authorAverette A.
dc.contributor.authorGoldberg J.M.
dc.contributor.authorShea T.
dc.contributor.authorYoung S.
dc.contributor.authorZeng Q.
dc.contributor.authorOliver B.G.
dc.contributor.authorBarton R.
dc.contributor.authorMetin B.
dc.contributor.authorHilmioğlu-Polat S.
dc.contributor.authorIlkit M.
dc.contributor.authorGräser Y.
dc.contributor.authorMartinez-Rossi N.M.
dc.contributor.authorWhite T.C.
dc.contributor.authorHeitman J.
dc.contributor.authorCuomo C.A.
dc.date.accessioned2019-10-26T21:15:09Z
dc.date.available2019-10-26T21:15:09Z
dc.date.issued2018
dc.departmentEge Üniversitesien_US
dc.description.abstractDermatophytes include fungal species that infect humans, as well as those that also infect other animals or only grow in the environment. The dermatophyte species Trichophyton rubrum is a frequent cause of skin infection in immunocompetent individuals. While members of the T. rubrum species complex have been further categorized based on various morphologies, their population structure and ability to undergo sexual reproduction are not well understood. In this study, we analyze a large set of T. rubrum and T. interdigitale isolates to examine mating types, evidence of mating, and genetic variation. We find that nearly all isolates of T. rubrum are of a single mating type, and that incubation with T. rubrum “morphotype” megninii isolates of the other mating type failed to induce sexual development. While the region around the mating type locus is characterized by a higher frequency of SNPs compared to other genomic regions, we find that the population is remarkably clonal, with highly conserved gene content, low levels of variation, and little evidence of recombination. These results support a model of recent transition to asexual growth when this species specialized to growth on human hosts. © 2018 Persinoti et al.en_US
dc.description.sponsorshipNational Human Genome Research Institute: U54-HG-003067 AI-39115-20, RO1 award AI-50113-13 Fundação de Amparo à Pesquisa do Estado de São Paulo: 13/19195-6, 12/22232-8 National Council for Scientific Research: 1059B191501539 Broad Instituteen_US
dc.description.sponsorshipWe thank the Broad Institute Genomics Platform for generating the DNA sequence described here, Yonathan Lewit for technical assistance, and Cecelia Wall for providing helpful comments on the manuscript. Financial support was provided by the National Human Genome Research Institute (grant number U54-HG-003067) to the Broad Institute, and by National Institutes of Health/National Institute of Allergy and Infectious Diseases R37 Method to Extend Research in Time award AI-39115-20 and RO1 award AI-50113-13 to J.H. This study was supported by The Scientific and Technological Research Council of Turkey-2219 Research Fellowship Programme for International Researchers project number 1059B191501539 to A.D. and by Brazilian funding agency Fundação de Amparo à Pesquisa do Estado de São Paulo Postdoctoral Fellowships 12/22232-8 and 13/19195-6 to G.F.P. --en_US
dc.identifier.doi10.1534/genetics.117.300573en_US
dc.identifier.endpage1669en_US
dc.identifier.issn0016-6731
dc.identifier.issue4en_US
dc.identifier.pmid29467168en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage1657en_US
dc.identifier.urihttps://doi.org/10.1534/genetics.117.300573
dc.identifier.urihttps://hdl.handle.net/11454/15961
dc.identifier.volume208en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherGenetics Society of Americaen_US
dc.relation.ispartofGeneticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDermatophyteen_US
dc.subjectGenome sequenceen_US
dc.subjectLysMen_US
dc.subjectMatingen_US
dc.subjectMLSTen_US
dc.subjectRecombinationen_US
dc.subjectTrichophyton interdigitaleen_US
dc.subjectTrichophyton rubrumen_US
dc.titleWhole-genome analysis illustrates global clonal population structure of the ubiquitous dermatophyte pathogen trichophyton rubrumen_US
dc.typeArticleen_US

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