Evaluation of Beta Cell Dysfunction by Mixed Meal Tolerance Test and Oral L-arginine in Patients with Newly Diagnosed Type 2 Diabetes Mellitus

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dc.contributor.authorOzbek, M.
dc.contributor.authorErdogan, M.
dc.contributor.authorKaradeniz, M.
dc.contributor.authorCetinkalp, S.
dc.contributor.authorOzgen, A. G.
dc.contributor.authorSaygili, F.
dc.contributor.authorYilmaz, C.
dc.contributor.authorTuzun, M.
dc.date.accessioned2019-10-27T21:19:53Z
dc.date.available2019-10-27T21:19:53Z
dc.date.issued2009
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground and aims: Defective insulin secretion is required for the development of frank diabetes mellitus. We evaluated the secretory response of pancreatic beta cells after the ingestion of mixed meal plus oral L-arginine in newly diagnosed type 2 diabetic patients. Materials and methods: Twenty-four newly diagnosed type 2 diabetic patients were enrolled in this study. All patients were ingested a mixed meal of 553 kcal. Serum insulin levels were measured at time 0 just before the mixed meal and at 1, 2, 3, 4 and 5 h after the ingestion of the mixed meal. Twenty-four hours later, all patients ingested mixed meal followed by oral 8g L-Arginine, and insulin levels were again measured at 0, 1, 2, 3, 4 and 5 h after the ingestion of the meal. Results: Insulin levels reached to peak values at the 2(nd) hour, and decreased to baseline levels at the 5(th) hour measurements both after the ingestion of mixed meal only and after the ingestion of mixed meal plus oral L-Arginine. First and 2(nd) hour insulin levels were significantly higher after the ingestion of mixed meal plus oral L-Arginine. Conclusion: In this study we used for the first time the combination of oral L-arginine with mixed meal test to evaluate the beta cell dysfunction in type 2 diabetic patients. Increments regarding serum insulin levels after the ingestion of mixed meal plus oral L-Arginine suggest that oral L-Arginine could be benefical for the evaluation of beta cell function and secretory defects.en_US
dc.identifier.doi10.1055/s-0029-1234087en_US
dc.identifier.endpage576en_US
dc.identifier.issn0947-7349
dc.identifier.issn1439-3646
dc.identifier.issue10en_US
dc.identifier.pmid19924604en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage573en_US
dc.identifier.urihttps://doi.org/10.1055/s-0029-1234087
dc.identifier.urihttps://hdl.handle.net/11454/44214
dc.identifier.volume117en_US
dc.identifier.wosWOS:000272242900004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherJohann Ambrosius Barth Verlag Medizinverlage Heidelberg Gmbhen_US
dc.relation.ispartofExperimental and Clinical Endocrinology & Diabetesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjecttype 2 diabetesen_US
dc.subjectL-Arginineen_US
dc.subjectmixed meal tolerance testen_US
dc.titleEvaluation of Beta Cell Dysfunction by Mixed Meal Tolerance Test and Oral L-arginine in Patients with Newly Diagnosed Type 2 Diabetes Mellitusen_US
dc.typeArticleen_US

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