Muscle mass as a modifier of stress response in acute ischemic stroke patients

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dc.authoridbugrul, ahmet/0000-0002-6208-2553
dc.contributor.authorArsava, Ethem Murat
dc.contributor.authorGungor, Levent
dc.contributor.authorSirin, Hadiye
dc.contributor.authorSorgun, Mine Hayriye
dc.contributor.authorAykac, Ozlem
dc.contributor.authorCaglayan, Hale Zeynep Batur
dc.contributor.authorKozak, Hasan Huseyin
dc.date.accessioned2024-08-31T07:49:48Z
dc.date.available2024-08-31T07:49:48Z
dc.date.issued2024
dc.departmentEge Üniversitesien_US
dc.description.abstractStroke triggers a systemic inflammatory response over the ensuing days after the cerebral insult. The age and comorbidities of the stroke population make them a vulnerable population for low muscle mass and sarcopenia, the latter being another clinical condition that is closely associated with inflammation, as shown by increased levels of pro-inflammatory biomarkers, including neutrophil-to-lymphocyte ratio (NLR). In this study, we evaluated the relationship between post-stroke NLR changes and muscle mass in a prospective cohort of acute ischemic stroke patients (n=102) enrolled in the Muscle Assessment in Stroke Study Turkey (MASS-TR). Admission lumbar computed tomography images were used to determine the cross-sectional muscle area of skeletal muscles at L3 vertebra level and calculate the skeletal muscle index (SMI). The median (IQR) SMI was 44.7 (39.1-52.5) cm(2)/m(2), and the NLR at admission and follow-up were 4.2 (3.0-10.5) and 9.4 (5.7-16.2), respectively. While there was no relationship between SMI and admission NLR, a significant inverse correlation was observed between SMI and follow-up NLR (r=-0.26; P=0.007). Lower SMI remained significantly associated (P=0.036) with higher follow-up NLR levels in multivariate analysis. Our findings highlight the importance of muscle mass as a novel factor related to the level of post-stroke stress response.en_US
dc.description.sponsorshipTurkish Neurological Society; Abbotten_US
dc.description.sponsorshipThis study was supported by the Turkish Neurological Society and through an unrestricted research grant from Abbott.en_US
dc.identifier.doi10.1038/s41598-024-60829-6
dc.identifier.issn2045-2322
dc.identifier.issue1en_US
dc.identifier.pmid38698153en_US
dc.identifier.scopus2-s2.0-85192030537en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1038/s41598-024-60829-6
dc.identifier.urihttps://hdl.handle.net/11454/105002
dc.identifier.volume14en_US
dc.identifier.wosWOS:001284629600094en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherNature Portfolioen_US
dc.relation.ispartofScientific Reportsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240831_Uen_US
dc.subjectNeutrophil Lymphocyte Ratioen_US
dc.subjectSkeletal-Muscleen_US
dc.subjectInflammatory Responseen_US
dc.subjectImmuneen_US
dc.subjectSarcopeniaen_US
dc.subjectThrombolysisen_US
dc.subjectTissueen_US
dc.titleMuscle mass as a modifier of stress response in acute ischemic stroke patientsen_US
dc.typeArticleen_US

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