Salivary Pro-Inflammatory Cytokines and Salivary Bacterial Challenge Effect on Dental Caries: A Clinico-Molecular Cross-Sectional Study

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dc.contributor.authorPakdemirli, Ahu
dc.contributor.authorKemaloğlu, Hande
dc.contributor.authorKılınç, Gülser
dc.contributor.authorEllidokuz, Hülya
dc.contributor.authorKocal, Gizem Calibasi
dc.contributor.authorDaşkın, Ezgi
dc.contributor.authorBaşpınar, Yasemin
dc.date.accessioned2023-01-12T20:30:26Z
dc.date.available2023-01-12T20:30:26Z
dc.date.issued2020
dc.departmentN/A/Departmenten_US
dc.description.abstractObjectives: Objective of this study is to determine the correlation between salivary cytokine concentrations and cariogram value high (C1) and low (C2) experience in people. In this direction, saliva cytokines showed a significant correlation with the patient’s caries experience.Patients and Methods: Unstimulated whole saliva samples were collected from 38 appropriate populations of patients aged between 20 to 57 years old. All patients’ DMF (decay/missing/filled) values were higher than 0. Twenty-one caries activity groups (C1) and 17 caries non-activity groups (C2) patients were collected for this study. Procedures of the clinical evaluation were the collection of saliva samples and oral examination. The whole saliva from 38 patients with C1 and C2 was investigated for the existence of GM-CSF, TNF?, IFN-g, IL-2, IL-4, IL-6, IL-8, and IL-10.Results: The study population consisted of 38 subjects with a mean age of 34.76±14.43 years. Likewise, there was a significant interaction between salivary flow rate, S. Mutans number, number of Lactobacillus, number of meals and IL-6, a significant difference in caries activity groups.Conclusion: Salivary cytokines demonstrated significant interactions to caries experience of the patient.en_US
dc.identifier.doi10.30621/jbachs.2020.920
dc.identifier.endpage81en_US
dc.identifier.issn2564-7288
dc.identifier.issue1en_US
dc.identifier.startpage77en_US
dc.identifier.trdizinid371231en_US
dc.identifier.urihttps://doi.org/10.30621/jbachs.2020.920
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/371231
dc.identifier.urihttps://hdl.handle.net/11454/80796
dc.identifier.volume4en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofJournal of Basic and Clinical Health Sciencesen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleSalivary Pro-Inflammatory Cytokines and Salivary Bacterial Challenge Effect on Dental Caries: A Clinico-Molecular Cross-Sectional Studyen_US
dc.typeArticleen_US

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