Serum Chitotriosidase Activity in Acute Coronary Syndrome

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dc.contributor.authorYildiz, Bekir Serhat
dc.contributor.authorBarutcuoglu, Burcu
dc.contributor.authorAlihanoglu, Yusuf Izzettin
dc.contributor.authorAlkan, Mustafa Beyazit
dc.contributor.authorBilgin, Murat
dc.contributor.authorGul, Ilker
dc.contributor.authorGungor, Hasan
dc.contributor.authorEsin, Fatma
dc.contributor.authorSayin, Ahmet
dc.contributor.authorZoghi, Mehdi
dc.date.accessioned2019-10-27T21:54:46Z
dc.date.available2019-10-27T21:54:46Z
dc.date.issued2013
dc.departmentEge Üniversitesien_US
dc.description.abstractAim: Inflammation is a critical participant in mediating all stages of cardiovascular disease. Studies related with chitotriosidase that was recently found to be relevant to arterial inflammation. In this study we evaluated activity of serum chitotriosidase in acute coronary syndrome patients and its relationship with cardiovascular events, cardiac enzymes and inflammatory indicators. Methods: We prospectively analyzed consecutive 30 patients with ST-segment elevation myocardial infarction, 30 patients with non ST-segment elevation myocardial infarction, 30 patients with unstable angina pectroris who were admitted to our intensive care unit and 30 healthy people (average age 56.86 +/- 10.44 years, 81 male) between Jaunary and June 2010. Details of baseline clinical characteristics, biochemical values, receiving treatment and basal ECG findings were recorded. Data of patients with coronary angiography were evaluated. Results: Cut off value of chitotriosidase was calculated 82.00 mmol.ml-1.h-1, with 83 percent sensitivity and 72 percent spesificity. The activity of chitotriosidase in acute coronary syndrome group was 88.85 +/- 23.08 mmol.ml-1.h-1, where as the control group was 68.47 +/- 28.44 mmol.ml-1.h-1, respectively p=0.001). The highest activity of chitotriosidase (96.11 +/- 19.77 mmol.ml-1.h-1) was found in ST-segment elevation myocardial infarction group and the minimal activity of chitotriosidase was in the control group (68.47 +/- 28.44 mmol.ml-1.h-1) (p=0.001). The activity of chitotriosidase in ST-segment elevation myocardial infarction and non ST-segment elevation myocardial infarction groups were significantly higher than control group (p=0.001 and p=0.045). When acute coronary syndrome groups compared to control; a positive correlation was found between chitotriosidase activity and hs-CRP (r =0.21, p=0.046), troponin T (r=0.25, p=0.016), creatine kinase-MB (r=0.20, p=0.059). Conclusion: The activity of chitotriosidase is increased in acute coronary syndrome patients. Chitotriosidase is higher in ST-segment elevation myocardial infaction group than non ST-segment elevation myocardial infarction and unstable angina pectoris group.en_US
dc.description.sponsorshipDepartment of Cardiology and Biochemistryen_US
dc.description.sponsorshipFunding for this work was obtained from the Department of Cardiology and Biochemistry.en_US
dc.identifier.doi10.5551/jat.13920en_US
dc.identifier.endpage141en_US
dc.identifier.issn1340-3478
dc.identifier.issn1880-3873
dc.identifier.issue2en_US
dc.identifier.pmid22986554en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage134en_US
dc.identifier.urihttps://doi.org/10.5551/jat.13920
dc.identifier.urihttps://hdl.handle.net/11454/48132
dc.identifier.volume20en_US
dc.identifier.wosWOS:000317783500002en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherJapan Atherosclerosis Socen_US
dc.relation.ispartofJournal of Atherosclerosis and Thrombosisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcute coronary syndromeen_US
dc.subjectChitotriosidaseen_US
dc.subjectMacrophageen_US
dc.subjecths-CRPen_US
dc.titleSerum Chitotriosidase Activity in Acute Coronary Syndromeen_US
dc.typeArticleen_US

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