Associations of interleukin (IL)-1 beta, IL-1 receptor antagonist, and IL-10 with dental caries

Basit Öğe Kaydı
dc.contributor.authorCogulu, Dilsah
dc.contributor.authorOnay, Huseyin
dc.contributor.authorOzdemir, Yasemin
dc.contributor.authorAslan, Gulcin I.
dc.contributor.authorÖzkınay, Ferda
dc.contributor.authorKutukculer, Necil
dc.contributor.authorEronat, Cemal
dc.date.accessioned2019-10-27T22:27:51Z
dc.date.available2019-10-27T22:27:51Z
dc.date.issued2015
dc.departmentEge Üniversitesien_US
dc.description.abstractStreptococcus mutans is important in dental caries. Although the role of cytokines in the pathogenesis of dental caries is not clear, components of Streptococcus mutans were found to stimulate production of pro-inflammatory cytokines. We examined the associations of interleukin (IL)-1 beta, IL-1 receptor antagonist (IL-1ra), and IL-10 with dental caries. Unstimulated whole saliva and blood samples were obtained from 108 children aged 6-12 years with high caries (decayed, missing, or filled teeth [dmft/DMFT] index >4, n = 37), moderate caries (dmft/DMFT = 1-4, n = 37), or caries-free (dmft/DMFT = 0, n = 34). Streptococcus mutans level was classified as low (<10(5) colony-forming units [CFU]/mL) or high (>= 10(5) CFU/mL). Saliva and serum concentrations of IL-1 beta, IL-1ra, and IL-10 were determined by ELISA. IL-1 beta, IL-1ra and IL-10 gene polymorphisms were genotyped using PCR and restriction fragment length polymorphism analysis. The chi-square, Mann-Whitney U, one-way ANOVA, posthoc, Fisher's exact, and t tests were used in statistical analysis. Dental caries was not correlated with salivary or serum concentrations of the studied cytokines. Streptococcus mutans level positively correlated with saliva IL-1 beta concentration and inversely correlated with saliva IL-1ra concentration. There was no correlation of IL-1 beta, IL-1ra, or IL-10 gene polymorphisms with dental caries. Streptococcus mutans is important in stimulating saliva IL-1 beta and inhibiting IL-1ra. Future studies of associations between cytokines and dental caries should investigate additional cytokines and enroll a larger number of participants.en_US
dc.identifier.doi10.2334/josnusd.57.31en_US
dc.identifier.endpage36en_US
dc.identifier.issn1343-4934
dc.identifier.issn1880-4926
dc.identifier.issue1en_US
dc.identifier.pmid25807906en_US
dc.identifier.startpage31en_US
dc.identifier.urihttps://doi.org/10.2334/josnusd.57.31
dc.identifier.urihttps://hdl.handle.net/11454/50785
dc.identifier.volume57en_US
dc.identifier.wosWOS:000351657900005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherNihon Univ, School Dentistryen_US
dc.relation.ispartofJournal of Oral Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectdental cariesen_US
dc.subjectStreptococcus mutansen_US
dc.subjectIL-1 betaen_US
dc.subjectIL-1raen_US
dc.subjectIL-10en_US
dc.titleAssociations of interleukin (IL)-1 beta, IL-1 receptor antagonist, and IL-10 with dental cariesen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu