A randomized comparison of different doses of intrathecal levobupivacaine combined with fentanyl for elective cesarean ection: Prospective, double-blinded study

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dc.contributor.authorGunusen I.
dc.contributor.authorKaraman S.
dc.contributor.authorSargin A.
dc.contributor.authorFirat V.
dc.date.accessioned2019-10-27T08:33:55Z
dc.date.available2019-10-27T08:33:55Z
dc.date.issued2011
dc.departmentEge Üniversitesien_US
dc.description.abstractPurpose Levobupivacaine may produce a sensory and motor block different from that produced by bupivacaine, which is the most popular local anesthetic in parturients undergoing cesarean section. The aim of this study was to investigate the block characteristics, the clinical efficacy, surgeon and patient satisfaction, and hemodynamic effects of using different doses of intrathecal plain levobupivacaine combined with fentanyl. Methods One hundred twenty women undergoing elective cesarean section with a combined spinal-epidural technique were enrolled. The parturients were randomly assigned to receive one of the following: levobupivacaine 5 mg (group 5), 7.5 mg (group 7.5) or 10 mg (group 10), all combined with fentanyl 25, 15 or 10 µg, respectively. Results Anesthesia was effective in 60, 82.5 and 100% of the patients in the levobupivacaine 5, 7.5 and 10 mg groups, respectively. Levobupivacaine 10 mg provided longer durations of analgesia and motor block and greater patient and surgeon satisfaction, although the incidence of hypotension was lower in groups 5 and 7.5 than in group 10 (12.5, 17.5 and 42.5%, respectively). Intraoperative epidural supplementation was higher in group 5 than in group 7.5 (40 and 17.5%, respectively), whereas no patients in group 10 were given an epidural bolus dose. Conclusions The incidence of hypotension was higher in the levobupivacaine 10 mg group, even though this group presented more effective anesthesia and greater patient and surgeon satisfaction compared with the levobupivacaine 5 and 7.5 mg groups. As a result, we believe that levobupivacaine 7.5 mg combined with fentanyl 15 µg is suitable for combined spinal-epidural anesthesia in elective cesarean section. © 2011 Japanese Society of Anesthesiologists.en_US
dc.identifier.doi10.1007/s00540-011-1097-4en_US
dc.identifier.endpage212en_US
dc.identifier.issn0913-8668
dc.identifier.issue2en_US
dc.identifier.pmid21298294en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage205en_US
dc.identifier.urihttps://doi.org/10.1007/s00540-011-1097-4
dc.identifier.urihttps://hdl.handle.net/11454/26920
dc.identifier.volume25en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofJournal of Anesthesiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCesarean sectionen_US
dc.subjectCombined spinal-epidural anesthesiaen_US
dc.subjectFentanylen_US
dc.subjectLevobupivacaineen_US
dc.titleA randomized comparison of different doses of intrathecal levobupivacaine combined with fentanyl for elective cesarean ection: Prospective, double-blinded studyen_US
dc.typeArticleen_US

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