Comparison of melatonin and oxytocin in the prevention of critical illness polyneuropathy in rats with experimentally induced sepsis

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dc.contributor.authorErbas, Oytun
dc.contributor.authorErgenoglu, Ahmet Mete
dc.contributor.authorAkdemir, Ali
dc.contributor.authorYeniel, Ahmet Ozgur
dc.contributor.authorTaskiran, Dilek
dc.date.accessioned2019-10-27T21:51:58Z
dc.date.available2019-10-27T21:51:58Z
dc.date.issued2013
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground: Critical illness polyneuropathy is an acute neuromuscular disorder of critically ill patients and is characterized by limb and respiratory muscle weakness. The purpose of the study was to evaluate the neuroprotective effects of melatonin (MEL) and oxytocin (OT) on the early stage of sepsis by recording compound muscle action potentials and measuring plasma tumor necrosis factor (TNF)-alpha levels, lipid peroxidation (malondialdehyde; MDA), and total antioxidant capacity. Materials and methods: One hundred adult male Sprague-Dawley rats were included in the study. The cecal ligation and puncture (CLP) procedure was performed to induce the sepsis model. MEL (10, 20, and 40 mg/kg), OT (0.4, 0.8, and 1.6 mg/kg), and a combination of MEL (20 mg/kg) and OT (0.8 mg/kg) were administered intraperitoneally in the first hour of surgery. Electromyography (EMG) studies were achieved 24 h after CLP surgery and then blood samples were collected for biochemical measurements. Results: EMG findings revealed that compound muscle action potential amplitude was significantly decreased and distal latency was prolonged in the CLP group compared with the sham group (P < 0.05 and P < 0.0005). Moreover, the animals that received CLP surgery showed significantly higher TNF-alpha and MDA levels and lower total antioxidant capacity values than the sham group. The administration of MEL and OT to rats significantly abolished the EMG alterations and suppressed oxidative stress and TNF-alpha release in CLP-induced rats. Conclusions: The inflammatory processes and imbalance in oxidative/antioxidative status play important roles in the pathogenesis of critical illness polyneuropathy. We suggest that both oxytocin and melatonin may have beneficial effects against sepsis-induced polyneuropathy in critical illness. (C) 2013 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.jss.2012.11.043en_US
dc.identifier.endpage320en_US
dc.identifier.issn0022-4804
dc.identifier.issn1095-8673
dc.identifier.issue1en_US
dc.identifier.pmid23312812en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage313en_US
dc.identifier.urihttps://doi.org/10.1016/j.jss.2012.11.043
dc.identifier.urihttps://hdl.handle.net/11454/47416
dc.identifier.volume183en_US
dc.identifier.wosWOS:000320599600046en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAcademic Press Inc Elsevier Scienceen_US
dc.relation.ispartofJournal of Surgical Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCritical illness polyneuropathyen_US
dc.subjectSepsisen_US
dc.subjectMelatoninen_US
dc.subjectOxytocinen_US
dc.subjectEMGen_US
dc.titleComparison of melatonin and oxytocin in the prevention of critical illness polyneuropathy in rats with experimentally induced sepsisen_US
dc.typeArticleen_US

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