Matrix metalloproteinase (MMP)-8 and tissue inhibitor of MMP-1 (TIMP-1) gene polymorphisms in generalized aggressive periodontitis: Gingival crevicular fluid MMP-8 and TIMP-1 levels and outcome of periodontal therapy

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dc.contributor.authorEmingil G.
dc.contributor.authorHan B.
dc.contributor.authorGürkan A.
dc.contributor.authorBerdeli A.
dc.contributor.authorTervahartiala T.
dc.contributor.authorSalo T.
dc.contributor.authorPussinen P.J.
dc.contributor.authorKöse T.
dc.contributor.authorAtilla G.
dc.contributor.authorSorsa T.
dc.date.accessioned2019-10-27T08:22:48Z
dc.date.available2019-10-27T08:22:48Z
dc.date.issued2014
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground: The aim of the present study is to investigate matrix metalloproteinase (MMP)-8 and tissue inhibitor of MMP-1 (TIMP-1) gene polymorphisms in generalized aggressive periodontitis (GAgP) and to assess the effects of MMP-8 and TIMP-1 genotypes on the outcomes of non-surgical periodontal therapy. Methods: Genomic DNA was obtained from peripheral blood of 100 patients with GAgP and 167 periodontally healthy controls. MMP-8 +17 C/G, -799 C/T, -381 A/G and TIMP-1 372 T/C, *429 T/G polymorphisms were determined by polymerase chain reaction-restriction fragment length polymorphism. Patients with GAgP received non-surgical periodontal therapy and were followed for 6 months. Clinical periodontal parameters and gingival crevicular fluid (GCF) samples were collected at baseline and at follow-up visits. GCF biomarkers were analyzed by immunofluorescence assay and enzyme-linked immunosorbent assay. Results: Distribution of the MMP-8-799 C/T genotypes was significantly different between the GAgP and control groups (P <0.005). TIMP-1 372 T/C and *429 T/G genotypes in males were also significantly different between study groups (P <0.004). GCF MMP-8 levels decreased until 3 months after non-surgical therapy compared with baseline in T and G alleles, as well as G and C allele carriers (P <0.0125), whereas no significant decreased was observed in non-carriers (P >0.0125). Conclusion: On the basis of the present findings, it can be suggested that MMP-8-799 C/T and TIMP-1 372 T/C, *429 T/G gene polymorphisms in males may be associated with the susceptibility to GAgP in the Turkish population.en_US
dc.identifier.doi10.1902/jop.2013.130365en_US
dc.identifier.endpage1080en_US
dc.identifier.issn0022-3492
dc.identifier.issue8en_US
dc.identifier.pmid24283658en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1070en_US
dc.identifier.urihttps://doi.org/10.1902/jop.2013.130365
dc.identifier.urihttps://hdl.handle.net/11454/26318
dc.identifier.volume85en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAmerican Academy of Periodontologyen_US
dc.relation.ispartofJournal of Periodontologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAggressive periodontitisen_US
dc.subjectGenesen_US
dc.subjectGingival crevicular fluiden_US
dc.subjectMatrix metalloproteinase 8en_US
dc.subjectPolymorphismen_US
dc.subjectTissue inhibitor of metalloproteinase-1en_US
dc.titleMatrix metalloproteinase (MMP)-8 and tissue inhibitor of MMP-1 (TIMP-1) gene polymorphisms in generalized aggressive periodontitis: Gingival crevicular fluid MMP-8 and TIMP-1 levels and outcome of periodontal therapyen_US
dc.typeArticleen_US

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