Diagnostic accuracy of interleukin-6, interleukin-8, and interleukin-10 for predicting bacteremia in children with febrile neutropenia [Febril Nötropenili Çocuklarda Bakteriyemiyi Öngörmede İnterlökin-6, İnterlökin-8, İnterlökin-10’un Tanısal Doğruluğu]

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dc.contributor.authorBal Z.Ş.
dc.contributor.authorÖzdemir N.K.
dc.contributor.authorŞen S.
dc.contributor.authorKarapınar D.Y.
dc.contributor.authorAzarsız E.
dc.contributor.authorAydemir Ş.
dc.contributor.authorVardar F.
dc.date.accessioned2019-10-27T08:04:22Z
dc.date.available2019-10-27T08:04:22Z
dc.date.issued2017
dc.departmentEge Üniversitesien_US
dc.description.abstractDespite improvements in diagnosis and treatment, infections are still a major cause of morbidity and mortality in children with febrile neutropenia. In the majority of febrile episodes, the source of infection cannot be defined. In this study, we aimed to identify the earlier predictors of bacteremia/fungemia and a useful cytokine to identify the source of infection and to discriminate the patients with culture-confirmed bacterial/fungal infection. The most sensitive cytokine was interleukin (IL)-10 and the most specific was IL-8 in predicting culture-confirmed cases. IL-8 had greater sensitivity and specificity in determination of gram-negative bacterial infections with a higher negative predictive value; therefore, IL-8 can be used particularly to rule out gram-negative bacterial infections. IL-6, IL-8, and IL-10 circulating levels were shown to be higher in cases of infection. Further studies are needed to recommend a routine practice for predicting culture-confirmed bacterial infections. © Copyright 2017 by Turkish Society of Hematology.en_US
dc.identifier.doi10.4274/tjh.2016.0434en_US
dc.identifier.endpage257en_US
dc.identifier.issn1300-7777
dc.identifier.issue3en_US
dc.identifier.pmid28148470en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage254en_US
dc.identifier.urihttps://doi.org/10.4274/tjh.2016.0434
dc.identifier.urihttps://hdl.handle.net/11454/25505
dc.identifier.volume34en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTurkish Society of Hematologyen_US
dc.relation.ispartofTurkish Journal of Hematologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBacteremiaen_US
dc.subjectFebrile neutropeniaen_US
dc.subjectIL-10en_US
dc.subjectIL-6en_US
dc.subjectIL-8en_US
dc.titleDiagnostic accuracy of interleukin-6, interleukin-8, and interleukin-10 for predicting bacteremia in children with febrile neutropenia [Febril Nötropenili Çocuklarda Bakteriyemiyi Öngörmede İnterlökin-6, İnterlökin-8, İnterlökin-10’un Tanısal Doğruluğu]en_US
dc.typeArticleen_US

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