Toll like receptor 4 and membrane-bound CD14 expressions in gingivitis, periodontitis and CsA-induced gingival overgrowth

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dc.contributor.authorBecerik, Sema
dc.contributor.authorOzsan, Nazan
dc.contributor.authorGurkan, Ali
dc.contributor.authorOzturk, Veil Ozgen
dc.contributor.authorAtilla, Gul
dc.contributor.authorEmingil, Gulnur
dc.date.accessioned2019-10-27T21:24:20Z
dc.date.available2019-10-27T21:24:20Z
dc.date.issued2011
dc.departmentEge Üniversitesien_US
dc.description.abstractObjective: Immune cell recognition of lipopolysaccharides via CD14 and Toll-like receptor 4 (TLR4) complexes plays a crucial role in linking innate and adaptive immune responses. This study was aimed to investigate the expression of TLR4 and membrane-bound CD14 (mCD14) in the gingival tissues of patients with gingivitis, periodontitis and CsA-induced gingival overgrowth. Design: Gingival tissues were obtained from 10 renal transplant patients receiving cyclosporine-A (CsA) and having gingival overgrowth (GO), 10 patients with chronic periodontitis, 10 generalized aggressive periodontitis, 10 gingivitis and 10 healthy subjects. Immunohistochemistry was performed in order to determine the localization of TLR4 and mCD14 in tissue specimens. Results: TLR4 and mCD14 expressions were detected in all tissues including healthy gingival biopsies. TLR4 and mCD14 positive cells were predominantly confined to the epithelium-connective tissue interface area, and were highly expressed in the basal cell layer of patients with CsA GO and chronic periodontitis, compared to healthy group (P < 0.05). Conclusion: The present study suggests that TLR4 and mCD14 protein expressions may be interrelated and appear to be associated with periodontal disease. CsA usage seemed not to affect TLR4 and mCD14 expressions in CsA induced GO tissues. (C) 2010 Elsevier Ltd. All rights reserved.en_US
dc.description.sponsorshipEge UniversityEge University [09-DIS-023]en_US
dc.description.sponsorshipThis study was supported by grants from Ege University Research Fund 09-DIS-023.en_US
dc.identifier.doi10.1016/j.archoralbio.2010.11.008en_US
dc.identifier.endpage465en_US
dc.identifier.issn0003-9969
dc.identifier.issue5en_US
dc.identifier.pmid21146153en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage456en_US
dc.identifier.urihttps://doi.org/10.1016/j.archoralbio.2010.11.008
dc.identifier.urihttps://hdl.handle.net/11454/44500
dc.identifier.volume56en_US
dc.identifier.wosWOS:000290138000006en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofArchives of Oral Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCD14en_US
dc.subjectTLR4en_US
dc.subjectCsAen_US
dc.subjectGingival overgrowthen_US
dc.subjectChronic periodontitisen_US
dc.subjectAggressive periodontitisen_US
dc.subjectGingivitisen_US
dc.titleToll like receptor 4 and membrane-bound CD14 expressions in gingivitis, periodontitis and CsA-induced gingival overgrowthen_US
dc.typeArticleen_US

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