Gingival crevicular fluid PGE2, IL-1ß, t-PA, PAI-2 levels in type 2 diabetes and relationship with periodontal disease
Küçük Resim Yok
Tarih
2008
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objectives: To evaluate if type 2 diabetes mellitus increase gingival crevicular fluid (GCF) levels of prostaglandin E2 (PGE2), interleukin-1beta (IL-1ß), tissue-type plasminogen activator (t-PA), and plasminogen activator inhibitor-2 (PAI-2). Design and methods: Seventeen type 2 diabetic patients with periodontal disease (DM), 17 otherwise healthy periodontally diseased patients (PD) and 17 systemically and periodontally healthy control subjects (H) were enrolled. Clinical periodontal measurements were recorded at six sites/tooth. GCF samples were analyzed by ELISA. Data were tested by statistical tests. Results: DM group revealed lower IL-1ß levels than PD group (p < 0.01). PGE2, t-PA and PAI-2 levels were similar in DM and PD groups (p > 0.05). PGE2, t-PA levels were higher in DM and PD groups than H group (p < 0.05). PAI-2 level was higher in DM group than H group (p < 0.05). GCF total amount of PGE2 in DM group exhibited significant correlations with all clinical periodontal measurements (p < 0.05). Conclusion: Type 2 diabetes in this study seems not to increase GCF levels of the evaluated inflammatory mediators. © 2008 The Canadian Society of Clinical Chemists.
Açıklama
Anahtar Kelimeler
Diabetes, ELISA, Gingival crevicular fluid, IL-1beta Periodontal disease, PAI-2, PGE2, t-PA
Kaynak
Clinical Biochemistry
WoS Q Değeri
Scopus Q Değeri
Q2
Cilt
41
Sayı
10.Nov
