Oxidative stress in relation to telomere length maintenance in vascular smooth muscle cells following balloon angioplasty

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dc.contributor.authorOzsarlak-Sozer, Gonen
dc.contributor.authorKerry, Zeliha
dc.contributor.authorGokce, Goksel
dc.contributor.authorOran, Ismail
dc.contributor.authorTopcu, Zeki
dc.date.accessioned2019-10-27T21:24:52Z
dc.date.available2019-10-27T21:24:52Z
dc.date.issued2011
dc.departmentEge Üniversitesien_US
dc.description.abstractTelomeres are specialized DNA-protein complexes found at the tips of linear chromosomes. In this study, we investigated the effects of oxidative stress on telomeric length distribution of proliferating vascular smooth muscle cells following balloon injury in single or combined treatment of rabbits with either buthionine sulfoximine or taurine. Exposure to oxidative stress increased the balloon injury whereas taurine treatment significantly diminished l-buthionine-sulfoximine-related intimal hyperplasia. Our results also showed that both variables had a significant influence on mean telomeric length distribution.en_US
dc.description.sponsorshipThe Scientific and Technological Research Council of TurkeyTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [SBAG-K-70]; SBAG-K-70, ZK) and Ege University Research FoundEge University [04ECZ012]en_US
dc.description.sponsorshipOur research was supported by grants from The Scientific and Technological Research Council of Turkey (SBAG-K-70, ZK) and Ege University Research Found (04ECZ012, GOS). This study was part of a Ph.D. thesis submitted to the Institute of Health Sciences of Ege University, Izmir, Turkey, by Ozsarlak-Sozer.en_US
dc.identifier.doi10.1007/s13105-010-0046-2en_US
dc.identifier.endpage42en_US
dc.identifier.issn1138-7548
dc.identifier.issn1877-8755
dc.identifier.issue1en_US
dc.identifier.pmid20924736en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage35en_US
dc.identifier.urihttps://doi.org/10.1007/s13105-010-0046-2
dc.identifier.urihttps://hdl.handle.net/11454/44682
dc.identifier.volume67en_US
dc.identifier.wosWOS:000287148900004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal of Physiology and Biochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectOxidative stressen_US
dc.subjectTelomere lengthen_US
dc.subjectBalloon angioplastyen_US
dc.subjectAtherosclerosisen_US
dc.titleOxidative stress in relation to telomere length maintenance in vascular smooth muscle cells following balloon angioplastyen_US
dc.typeArticleen_US

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