Determination of In Vivo Behavior of Mitomycin C-Loaded O/W Soybean Oil Microemulsion and Mitomycin C Solution Via Gamma Camera Imaging

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dc.contributor.authorKotmakci, Mustafa
dc.contributor.authorKantarci, Gulten
dc.contributor.authorAsikoglu, Makbule
dc.contributor.authorOzkilic, Hayal
dc.contributor.authorErtan, Gokhan
dc.date.accessioned2019-10-27T22:08:40Z
dc.date.available2019-10-27T22:08:40Z
dc.date.issued2013
dc.departmentEge Üniversitesien_US
dc.description.abstractIn this study, a microemulsion system was evaluated for delivery of mitomycin C (MMC). To track the distribution of the formulated drug after intravenous administration, radiochemical labeling and gamma scintigraphy imaging were used. The aim was to evaluate a microemulsion system for intravenous delivery of MMC and to compare its in vivo behavior with that of the MMC solution. For microemulsion formulation, soybean oil was used as the oil phase. Lecithin and Tween 80 were surfactants and ethanol was the cosurfactant. To understand the whole body localization of MMC-loaded microemulsion, MMC was labeled with radioactive technetium and gamma scintigraphy was applied for visualization of drug distribution. Radioactivity in the bladder 30 minutes after injection of the MMC solution was observed, according to static gamma camera images. This shows that urinary excretion of the latter starts very soon. On the other hand, no radioactivity appeared in the urinary bladder during the 90 minutes following the administration of MMC-loaded microemulsion. The unabated radioactivity in the liver during the experiment shows that the localization of microemulsion formulation in the liver is stable. In the light of the foregoing, it is suggested that this microemulsion formulation may be an appropriate carrier system for anticancer agents by intravenous delivery in hepatic cancer chemotherapy.en_US
dc.description.sponsorshipScientific Research Fund of Ege UniversityEge University [08.ECZ.018]en_US
dc.description.sponsorshipThis study was supported by the Scientific Research Fund of Ege University by project number 08.ECZ.018.en_US
dc.identifier.doi10.1089/cbr.2012.1428en_US
dc.identifier.endpage533en_US
dc.identifier.issn1084-9785
dc.identifier.issue7en_US
dc.identifier.pmid23659461en_US
dc.identifier.startpage530en_US
dc.identifier.urihttps://doi.org/10.1089/cbr.2012.1428
dc.identifier.urihttps://hdl.handle.net/11454/49215
dc.identifier.volume28en_US
dc.identifier.wosWOS:000322986900005en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMary Ann Liebert, Incen_US
dc.relation.ispartofCancer Biotherapy and Radiopharmaceuticalsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectintravenous deliveryen_US
dc.subjectliveren_US
dc.subjectmitomycin Cen_US
dc.subjecttargetingen_US
dc.titleDetermination of In Vivo Behavior of Mitomycin C-Loaded O/W Soybean Oil Microemulsion and Mitomycin C Solution Via Gamma Camera Imagingen_US
dc.typeArticleen_US

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