Successful Treatment Response with Aripiprazole Augmentation of SSRIs in Refractory Obsessive–Compulsive Disorder in Childhood

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dc.contributor.authorAkyol Ardic U.
dc.contributor.authorErcan E.S.
dc.contributor.authorKutlu A.
dc.contributor.authorYuce D.
dc.contributor.authorIpci M.
dc.contributor.authorInci S.B.
dc.date.accessioned2019-10-27T08:03:31Z
dc.date.available2019-10-27T08:03:31Z
dc.date.issued2017
dc.departmentEge Üniversitesien_US
dc.description.abstractThe aim of this study is to evaluate the aripiprazole augmentation of selective seratonine reuptake inhibitors (SSRIs) in children and adolescents with treatment-resistant OCD. Forty-eight children and adolescents (14 girls, 34 boys), who are non-responders to treatment with at least two types of SSRIs and CBT, were administered a 12-week of augmentation. Children’s Yale-Brown Obsessive Compulsive Scale (CY-BOCS), and Clinical Global Impression-Severity and Improvement (CGI-S and CGI-I) sub-scales were used for evaluation of the treatment outcomes. The results showed that total CY-BOCS scores were decreased from 33.3 ± 7.5 to 11.7 ± 9.3 (p < 0.001), CGI-S scores decreased from 6.3 ± 0.9 to 2.7 ± 1.6 (p < 0.001), and CGI-I scores improved from 4.3 ± 0.6 to 2.2 ± 1.1 (p < 0.001). Sensitivity analyses in 29 patients without SSRI dose escalation along with aripiprazole augmentation have also revealed that improvement effect was still significant, and CY-BOCS scores were improved from 34.2 ± 7.9 to 13 ± 10.3, CGI-S improved from 6.4 ± 1.0 to 3.0 ± 1.7, and CGI-I improved from 4.4 ± 1.0 to 2.3 ± 1.1 (p < 0.001 for all). Analyses revealed that a significant clinical improvement has been observed with aripiprazole augmentation. Aripiprazole augmentation of SSRIs is a promising strategy in the management of treatment-refractory OCD children and adolescents. © 2016, Springer Science+Business Media New York.en_US
dc.identifier.doi10.1007/s10578-016-0694-8en_US
dc.identifier.endpage704en_US
dc.identifier.issn0009-398X
dc.identifier.issue5en_US
dc.identifier.pmid27812841en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage699en_US
dc.identifier.urihttps://doi.org/10.1007/s10578-016-0694-8
dc.identifier.urihttps://hdl.handle.net/11454/25373
dc.identifier.volume48en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer New York LLCen_US
dc.relation.ispartofChild Psychiatry and Human Developmenten_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAdolescentsen_US
dc.subjectAripiprazoleen_US
dc.subjectAugmentationen_US
dc.subjectChildrenen_US
dc.subjectObsessive–compulsive disorderen_US
dc.titleSuccessful Treatment Response with Aripiprazole Augmentation of SSRIs in Refractory Obsessive–Compulsive Disorder in Childhooden_US
dc.typeArticleen_US

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