Effect of telmisartan on vascular endothelium in hypertensive and type 2 diabetic hypertensive patients

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dc.contributor.authorBarutcuoglu, Burcu
dc.contributor.authorParildar, Zuhal
dc.contributor.authorMutaf, M. Isil
dc.contributor.authorOzmen, Dilek
dc.contributor.authorAlioglu, Emin
dc.contributor.authorHabif, Sara
dc.contributor.authorBayindir, Oya
dc.date.accessioned2019-10-27T21:18:33Z
dc.date.available2019-10-27T21:18:33Z
dc.date.issued2010
dc.departmentEge Üniversitesien_US
dc.description.abstractAim: Hypertension and type 2 diabetes mellitus (DM) cause endothelial dysfunction and may result in cardiovascular disease. The aim of this study was to assess endothelial dysfunction in essential hypertensives, and normotensive and hypertensive type 2 diabetics and to evaluate the effect of telmisartan on endothelium in hypertensives. Materials and methods: Eighteen essential hypertensives (group 1), 16 type 2 diabetic hypertensives (group 2), 10 type 2 diabetic normotensives (group 3), and 10 control subjects (group 4) were included in this study Groups 1 and 2 received 40 mg/day telmisartan for 12 weeks and were evaluated at the beginning and end. Groups 3 and 4 were evaluated once by serum nitrate (NO), vascular cell adhesion molecule-1 (VCAM-1), platelet endothelial cell adhesion molecule-1 (PECAM-1), thrombomodulin (TM), plasminogen activator inhibitor-1 (PAI-1), paraoxonase (PON1), urine microalbumin (MAU), and endothelium dependent flow mediated dilation (FMD). Results: In groups I, 2, and 3, PAI-1 (P < 0.001, for all) and MAU (P = 0.012, P = 0.006, P = 0.004, respectively) were significantly higher than they were in group 4. In group 2, PON1 was significantly lower than it was in groups 4 and 1 (P = 0.028, P < 0.001 respectively), and NO was significantly lower than it was in groups I, 3, and 4 (P < 0.001, for all). Brachial artery FMD was significantly lower in groups 1 and 2 than it was in group 4 and EMD in group 2 was lower than it was in group 3. After telmisartan treatment there were significant increases in PON1 in groups 1 and 2, and in TM in group 2. Conclusion: Type 2 DM and essential hypertension result in endothelial dysfunction. Telmisartan decreases blood pressure to normal ranges in hypertensives, but it has a minimal role in improvement of endothelial dysfunction.en_US
dc.identifier.doi10.3906/sag-0807-11
dc.identifier.endpage248en_US
dc.identifier.issn1300-0144
dc.identifier.issue2en_US
dc.identifier.startpage239en_US
dc.identifier.urihttps://doi.org/10.3906/sag-0807-11
dc.identifier.urihttps://hdl.handle.net/11454/44003
dc.identifier.volume40en_US
dc.identifier.wosWOS:000278446800011en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherTubitak Scientific & Technical Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEndothelial dysfunctionen_US
dc.subjectessential hypertensionen_US
dc.subjecttype 2 diabetes mellitusen_US
dc.titleEffect of telmisartan on vascular endothelium in hypertensive and type 2 diabetic hypertensive patientsen_US
dc.typeArticleen_US

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