Fatty acid composition and preclinical resarches on Anthemis wiedemanniana Fisch Mey.: Discovery of a new anti-inflammatory agent

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dc.contributor.authorGonenc, Tuba Mert
dc.contributor.authorAkkol, Esra Kupeli
dc.contributor.authorSuntar, Ipek
dc.contributor.authorErdogan, Tugce Fafal
dc.contributor.authorKivcak, Bijen
dc.date.accessioned2019-10-27T22:06:05Z
dc.date.available2019-10-27T22:06:05Z
dc.date.issued2014
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground: Anthemis species have been used for the treatment of gastrointestinal disorders, hemorrhoid, stomachache and inflammatory diseases in Turkish folk medicine. Anthemis wiedemanniana Fisch. And Mey. is an endemic plant used as painkiller, antispasmodic, sedative and for the treatment of urinary inflammations. Objective: The objective of the present study is to evaluate the anti-inflamatory activity of the extracts of A. wiedemanniana by using in vivo methods. Materials and Methods: Carrageenan-, PGE 2 - and serotonin-induced hind paw edema, 12-O-tetradecanoyl-13-acetate (TPA)-induced mouse ear edema and acetic acid-induced increase in capillary permeability models were used for the anti-inflammatory activity assessment. Moreover, the fatty acid composition of A. wiedemanniana was investigated by gas chromatography (GC). Results: n-Hexane, diethyl ether and total sesquiterpene lactone extracts exhibited significant inhibition in carrageenan-induced hind paw edema and acetic acid-induced increase in capillary permeability model. n-Hexane and total sesquiterperne lactone extracts showed anti-inflammatory activity in PGE 2 - and serotonin-induced hind paw edema model. However none of the extracts displayed significant activity in TPA-induced ear edema model in mice. C 4:0 (Buthyric acid), C 20:0 (Arachidic acid) and C 16:1 (Palmitoleik acid) were found to be the major fatty acids in these species. Saturated fatty acids (SFA) were found in higher amounts than monounsaturated fatty acids and polyunsaturated fatty acids. SFAs were determined as 63.17%, UFAs as 20.89% and PuFAs as 15.95%. Conclusion: This study confirms the traditional usage of A. wiedemanniana for inflammatory diseases.en_US
dc.identifier.doi10.4103/0973-1296.126660en_US
dc.identifier.endpage60en_US
dc.identifier.issn0973-1296
dc.identifier.issn0976-4062
dc.identifier.issue37en_US
dc.identifier.pmid24696546en_US
dc.identifier.startpage53en_US
dc.identifier.urihttps://doi.org/10.4103/0973-1296.126660
dc.identifier.urihttps://hdl.handle.net/11454/48699
dc.identifier.volume10en_US
dc.identifier.wosWOS:000331062600008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMedknow Publications & Media Pvt Ltden_US
dc.relation.ispartofPharmacognosy Magazineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAnthemis wiedemannianaen_US
dc.subjectAsteraceaeen_US
dc.subjectAnti-inflammatoryen_US
dc.subjectfatty aciden_US
dc.titleFatty acid composition and preclinical resarches on Anthemis wiedemanniana Fisch Mey.: Discovery of a new anti-inflammatory agenten_US
dc.typeArticleen_US

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