New electroactive hybridization indicators 2-phthalimido-N-substitutedphenylethanesulfonamide derivatives for biosensor applications: Ring substituent effect on interaction between compound and DNA

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dc.contributor.authorOzkan-Ariksoysal D.
dc.contributor.authorAkgul O.
dc.contributor.authorAydinlik S.
dc.contributor.authorTopkaya S.N.
dc.contributor.authorAladag N.
dc.contributor.authorOzsoz M.
dc.date.accessioned2019-10-27T08:34:29Z
dc.date.available2019-10-27T08:34:29Z
dc.date.issued2010
dc.departmentEge Üniversitesien_US
dc.description.abstractIn this work, an electrochemical DNA-based sensor was developed for the detection of the interaction between the anticonvulsant compounds 2-phthalimido-N-substituted phenylethanesulfonamides (PMPES-derivatives) and 24-mer short DNA sequences by using differential pulse voltammetry (DPV) based on both compound and guanine oxidation signals at the renewable carbon graphite electrode (CGE) surface. The influence of compounds on DNA showed differences depending on the nature and position of the substituent on the N-phenyl ring. Compounds bearing 3-methoxy, 4-chloro and 2,6-dimethyl substituents bind to single stranded probe DNA more strongly than the other derivatives of PMPES. Thus, these compounds were evaluated for use as an electrochemical hybridization label (indicator). © 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.en_US
dc.identifier.doi10.1002/elan.201000128
dc.identifier.endpage2234en_US
dc.identifier.issn1040-0397
dc.identifier.issn1040-0397en_US
dc.identifier.issue19en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage2225en_US
dc.identifier.urihttps://doi.org/10.1002/elan.201000128
dc.identifier.urihttps://hdl.handle.net/11454/27053
dc.identifier.volume22en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.relation.ispartofElectroanalysisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject2-Phthalimido-N-substitutedphenylethanesulfonamidesen_US
dc.subjectBiosensorsen_US
dc.subjectCarbon graphite electrodeen_US
dc.subjectDNAen_US
dc.subjectDrug-DNA interactionsen_US
dc.subjectGuanineen_US
dc.subjectHybridizationen_US
dc.titleNew electroactive hybridization indicators 2-phthalimido-N-substitutedphenylethanesulfonamide derivatives for biosensor applications: Ring substituent effect on interaction between compound and DNAen_US
dc.typeArticleen_US

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