Tissue Decellularization- A Novel Modality in Recapitulation of Extracellular Matrix

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dc.contributor.authorCeliktas O.Y.
dc.contributor.authorArslan Y.
dc.date.accessioned2024-08-31T07:42:14Z
dc.date.available2024-08-31T07:42:14Z
dc.date.issued2023
dc.departmentEge Üniversitesien_US
dc.description2023 International Conference on Research in Education and Science, ICRES 2023 -- 18 May 2023 through 21 May 2023 -- Cappadocia -- 196574en_US
dc.description.abstractThe Extracellular matrix (ECM) is a highly organized three-dimensional (3D) network of proteins and biomolecules essential for all tissue types. Many biomimetic matrices have been developed using protein compositions of the ECM to emulate the native ECM of the tissue. Biomaterials composed of ECM can be prepared by processes that involve the decellularization of tissues and organs. Physical, chemical, and biological approaches are applied in combination to lyses the cells, followed by extensive washing procedures to remove cellular components. Decellularization and sterilization of the decellularized ECM (dECM) are highly effective in obtaining a biomaterial with the desired properties for the targeted clinical application. dECM-based biomaterials encompass mixtures of various biomolecules that regulate cell adhesion, proliferation, migration, and differentiation, such as glycosaminoglycans (GAGs), proteoglycans (PGs), glycoproteins, and structural proteins (i.e., collagens). Therefore, the selected decellularization and sterilization methods should have a minimal negative impact on the biochemical and morphological composition and mechanical properties of the dECM. This study presents an overview of decellularization methods and their effects on ECM structure and composition along with a PEST (political, economic, social, and technological factors) analysis that reveals the status of the dECM-based biomaterials in the market. © 2023 Published by the ISTES Organizationen_US
dc.description.sponsorshipTürkiye Bilimsel ve Teknolojik Araştırma Kurumu, TÜBİTAK, (221S447)en_US
dc.identifier.endpage2115en_US
dc.identifier.isbn978-195209244-2
dc.identifier.issn2833-6747
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85184321893en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage2104en_US
dc.identifier.urihttps://hdl.handle.net/11454/103800
dc.identifier.volume9en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherThe International Society for Technology Education and Scienceen_US
dc.relation.ispartofProceedings of International Conference on Research in Education and Scienceen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240831_Uen_US
dc.subjectBiomaterialsen_US
dc.subjectExtracellular Matrixen_US
dc.subjectProteinsen_US
dc.subjectTissue Decellularizationen_US
dc.subjectTissue Engineeringen_US
dc.titleTissue Decellularization- A Novel Modality in Recapitulation of Extracellular Matrixen_US
dc.typeConference Objecten_US

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