Tissue Decellularization- A Novel Modality in Recapitulation of Extracellular Matrix
Küçük Resim Yok
Tarih
2023
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
The International Society for Technology Education and Science
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The Extracellular matrix (ECM) is a highly organized three-dimensional (3D) network of proteins and biomolecules essential for all tissue types. Many biomimetic matrices have been developed using protein compositions of the ECM to emulate the native ECM of the tissue. Biomaterials composed of ECM can be prepared by processes that involve the decellularization of tissues and organs. Physical, chemical, and biological approaches are applied in combination to lyses the cells, followed by extensive washing procedures to remove cellular components. Decellularization and sterilization of the decellularized ECM (dECM) are highly effective in obtaining a biomaterial with the desired properties for the targeted clinical application. dECM-based biomaterials encompass mixtures of various biomolecules that regulate cell adhesion, proliferation, migration, and differentiation, such as glycosaminoglycans (GAGs), proteoglycans (PGs), glycoproteins, and structural proteins (i.e., collagens). Therefore, the selected decellularization and sterilization methods should have a minimal negative impact on the biochemical and morphological composition and mechanical properties of the dECM. This study presents an overview of decellularization methods and their effects on ECM structure and composition along with a PEST (political, economic, social, and technological factors) analysis that reveals the status of the dECM-based biomaterials in the market. © 2023 Published by the ISTES Organization
Açıklama
2023 International Conference on Research in Education and Science, ICRES 2023 -- 18 May 2023 through 21 May 2023 -- Cappadocia -- 196574
Anahtar Kelimeler
Biomaterials, Extracellular Matrix, Proteins, Tissue Decellularization, Tissue Engineering
Kaynak
Proceedings of International Conference on Research in Education and Science
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
9
Sayı
1
