A New Concept in Treatment of Burn Injury Controlled Slow-Release Granulocyte-Monocyte Colony-Stimulating Factor Chitosan Gel System

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dc.contributor.authorSimsek, Serife
dc.contributor.authorCanter, Halil Ibrahim
dc.contributor.authorKonas, Ersoy
dc.contributor.authorKorkusuz, Petek
dc.contributor.authorDemir, Devrim
dc.contributor.authorOner, Filiz
dc.contributor.authorUnsal, Ibrahim
dc.contributor.authorMavili, Mehmet Emin
dc.date.accessioned2019-10-27T21:35:20Z
dc.date.available2019-10-27T21:35:20Z
dc.date.issued2011
dc.departmentEge Üniversitesien_US
dc.description.abstractObjective: The aim of the study is to investigate the effectiveness of the controlled slow-release granulocyte-monocyte colony-stimulating factor (GM-CSF) system in burn wound healing. Material and Methods: In vivo effect of controlled slow-release GM-CSF from chitosan gel on burn wound healing was evaluated on 18 Wistar-Albino rats, weighing between 250 and 300 g. They were randomly divided into 3 groups; (1) burned only group (n = 6), (2) burned + chitosan group (n = 6), (3) burned + chitosan + GM-CSF group (n = 6). Wound area was measured macroscopically. Hematoxylin and eosin and Masson's trichrome stained sections were evaluated for wound healing and tissue response to the polymer. Results: The best healing process was observed with the controlled slow-release GM-CSF-applied group (group 3) in which the wound area was significantly narrowed. Conclusion: The study demonstrated the positive contribution of the single-dose controlled slow-release GM-CSF from chitosan gel on burn wound healing.en_US
dc.identifier.doi10.1097/SAP.0b013e31822af865en_US
dc.identifier.endpage588en_US
dc.identifier.issn0148-7043
dc.identifier.issue6en_US
dc.identifier.pmid22123539en_US
dc.identifier.startpage583en_US
dc.identifier.urihttps://doi.org/10.1097/SAP.0b013e31822af865
dc.identifier.urihttps://hdl.handle.net/11454/45838
dc.identifier.volume67en_US
dc.identifier.wosWOS:000298085900015en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofAnnals of Plastic Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcontrolled slow-releaseen_US
dc.subjectGM-CSFen_US
dc.subjectchitosanen_US
dc.subjectburnen_US
dc.titleA New Concept in Treatment of Burn Injury Controlled Slow-Release Granulocyte-Monocyte Colony-Stimulating Factor Chitosan Gel Systemen_US
dc.typeArticleen_US

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