The Effects of Prenatal Stress on Cortical and Hippocampal Gene Expression Profiles of DNA Methyltransferases and Histone Deacetylases in Female Rats

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dc.contributor.authorTurunc, Ezgi
dc.contributor.authorUyanıkgil, Yiğit
dc.contributor.authorYalçın, Ayfer
dc.contributor.authorTemiz, Tijen
dc.date.accessioned2024-08-31T07:31:15Z
dc.date.available2024-08-31T07:31:15Z
dc.date.issued2022
dc.departmentEge Üniversitesien_US
dc.description.abstractThe aim of this study was to investigate the effects of prenatal stress (PS) on mRNA levels of DNA methyltransferases (DNMTs) and histone deacetylases (HDACs) in cerebral cortex and hippocampus of female rats. PS was induced in rats with dexamethasone (Dex). From gestation day 14 to 21, pregnant rats were injected daily with Dex (100 ?g/kg) or saline. After birth, at 3 months of age, female rats were decapitated (n=5). The effects of Dex on epigenetic mechanisms were investigated by real-time PCR through mRNA levels of DNMT1, DNMT3a, DNMT3b, HDAC1 and HDAC2. Statistical significant differences were determined with one-way analysis of variance. Prenatal Dex exposure caused significant increases in DNMT3a, HDAC1 and HDAC2 mRNA levels in cortex and hippocampus. We further found that DNMT3b mRNA levels significantly increased in hippocampus but decreased in cortex of Dex group. No significant differences were found in DNMT1 mRNA levels. It was concluded that PS may trigger dysregulation of epigenetic mechanisms in cortex and hippocampus of female rats through alterations in gene expression profiles of DNMT3a, DNMT3b, HDAC1 and HDAC2.en_US
dc.identifier.doi10.18185/erzifbed.1126806
dc.identifier.endpage621en_US
dc.identifier.issn1307-9085
dc.identifier.issn2149-4584
dc.identifier.issue2en_US
dc.identifier.startpage609en_US
dc.identifier.trdizinid1161378en_US
dc.identifier.urihttps://doi.org/10.18185/erzifbed.1126806
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1161378
dc.identifier.urihttps://hdl.handle.net/11454/103380
dc.identifier.volume15en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofErzincan Üniversitesi Fen Bilimleri Enstitüsü Dergisien_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240831_Uen_US
dc.subjectPrenatal stressen_US
dc.subjectdexamethasoneen_US
dc.subjectDNA methyltransferaseen_US
dc.subjecthistone deacetylaseen_US
dc.subjectfemale raten_US
dc.titleThe Effects of Prenatal Stress on Cortical and Hippocampal Gene Expression Profiles of DNA Methyltransferases and Histone Deacetylases in Female Ratsen_US
dc.typeArticleen_US

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