Total phenolic contents, free radical scavenging activities and inhibitory effects on the activation of NF-kappa B of eight Centaurea L. species

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dc.contributor.authorKaramenderes, Canan
dc.contributor.authorKonyalioglu, Sibel
dc.contributor.authorKhan, Shabana
dc.contributor.authorKhan, Ikhlas A.
dc.date.accessioned2019-10-27T19:34:56Z
dc.date.available2019-10-27T19:34:56Z
dc.date.issued2007
dc.departmentEge Üniversitesien_US
dc.description.abstractExtracts obtained from aerial parts of eight Centaurea L. (Asteraceae) species (C. calolepis, C. cariensis subsp. maculiceps, C. cariensis subsp. microlepis, C. hierapolitana, C. cadmea, C. ensiformis, C. depressa and C. urvillei subsp. urvillei), were tested for their free radical scavenging activity (FRSA) in the DPPH screening assay, for their in vitro antiinflammatory activity in the reporter gene assay for inhibition of transcription factor NF-kappa B and for their total phenolic content. Methanol extracts (0.25 mg/4 mL) of C. urvillei, C. cadmea and C. ensiformis showed strong antioxidant activity with 90.41 +/- 2.98%, 86.66 +/- 2.67% and 86.19 +/- 2.94% FRSA, respectively. Antioxidant capacity results were consistent with the total phenolic content. Chloroform extracts of C. hierapolitana, C. calolepis and C. cadmea showed strong in vitro antiinflammatory activity with IC50 values of 2.5, 4.4 and 6.2 mu g/mL, respectively. Copyright (c) 2007 John Wiley & Sons, Ltd.en_US
dc.identifier.doi10.1002/ptr.2097en_US
dc.identifier.endpage491en_US
dc.identifier.issn0951-418X
dc.identifier.issue5en_US
dc.identifier.pmid17245684en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage488en_US
dc.identifier.urihttps://doi.org/10.1002/ptr.2097
dc.identifier.urihttps://hdl.handle.net/11454/39673
dc.identifier.volume21en_US
dc.identifier.wosWOS:000246163500020en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherJohn Wiley & Sons Ltden_US
dc.relation.ispartofPhytotherapy Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAsteraceaeen_US
dc.subjectCentaureaen_US
dc.subjectantioxidanten_US
dc.subjectantiinflammatoryen_US
dc.subjectNF-kappa Ben_US
dc.subjectDPPHen_US
dc.titleTotal phenolic contents, free radical scavenging activities and inhibitory effects on the activation of NF-kappa B of eight Centaurea L. speciesen_US
dc.typeArticleen_US

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