Interleukin-8 is increased in chronic kidney disease in children, but not related to cardiovascular disease

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dc.authorscopusid57281213900
dc.authorscopusid57203459114
dc.authorscopusid57202990242
dc.authorscopusid57204543360
dc.authorscopusid7005075504
dc.contributor.authorTuncay, Secil Conkar
dc.contributor.authorDogan, Eser
dc.contributor.authorHakverdi, Gulden
dc.contributor.authorTutar, Zulal Ulger
dc.contributor.authorMir, Sevgi
dc.date.accessioned2023-01-12T20:11:12Z
dc.date.available2023-01-12T20:11:12Z
dc.date.issued2021
dc.departmentN/A/Departmenten_US
dc.description.abstractIntroduction: In this study, we aimed to detect the cytokine that is involved in the early stage of chronic kidney disease and associated with cardiovascular disease. Methods: We included 50 patients who were diagnosed with predialytic chronic kidney disease and 30 healthy pediatric patients in Ege University Medical Faculty Pediatric Clinic, Izmir/Turkey. Interleukin-8 (IL-8), interleukin-10 (IL-10), interleukin-13 (IL-13), and transforming grow factor-beta 1 (TGF-beta 1) levels (pg/mL) were measured by ELISA. Carotid-femoral pulse wave velocity (PWV), augmentation index (Aix), carotid intima media thickness (cIMT), and left ventricular mass index (LVMI) were evaluated as markers of cardiovascular disease. The presence of a cardiovascular disease marker was defined as an abnormality in any of the parameters (cIMT, PWV, Aix, and left ventricular mass index (SVKI)). The patient group was divided into two groups as with and without cardiovascular disease. Results: Mean Aix and PWV values were higher in CKD patients than controls (Aix: CKD 32.8 +/- 11.11%, healthy subjects: 6.74 +/- 6.58%, PWV CKD: 7.31 +/- 4.34m/s, healthy subjects: 3.42 +/- 3.01m/s, respectively; p=0.02, p=0.03). The serum IL-8 levels of CKD were significantly higher than of healthy subjects 568.48 +/- 487.35pg/mL, 33.67 +/- 47.47pg/ mL, respectively (p<0.001). There was no statistically significant difference between IL-8, IL-10, IL-13, TGF-1, in CKD patients with and without cardiovascular disease (p>0.05). Discussion: IL-8 is the sole cytokine that increases in pediatric patients with chronic kidney disease among other cytokines (IL-10, IL-13 and TGF-beta 1). However, we did not show that IL-8 is related to the presence of cardiovascular disease.en_US
dc.identifier.doi10.1590/2175-8239-JBN-2020-0225
dc.identifier.endpage364en_US
dc.identifier.issn0101-2800
dc.identifier.issn2175-8239
dc.identifier.issue3en_US
dc.identifier.pmid33711092en_US
dc.identifier.scopus2-s2.0-85116173222en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage359en_US
dc.identifier.urihttps://doi.org/10.1590/2175-8239-JBN-2020-0225
dc.identifier.urihttps://hdl.handle.net/11454/78058
dc.identifier.volume43en_US
dc.identifier.wosWOS:000852619700011en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSoc Brasileira Nefrologiaen_US
dc.relation.ispartofJornal Brasileiro De Nefrologiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectRenal Insufficiencyen_US
dc.subjectChronicen_US
dc.subjectChilden_US
dc.subjectCardiovascular Diseasesen_US
dc.subjectInterleukin-8en_US
dc.subjectCytokinesen_US
dc.subjectAdolescents Reference Valuesen_US
dc.subjectIntima-Media Thicknessen_US
dc.subjectPulse-Wave Velocityen_US
dc.subjectYoung-Adultsen_US
dc.subjectInflammationen_US
dc.subjectMortalityen_US
dc.subjectDialysisen_US
dc.titleInterleukin-8 is increased in chronic kidney disease in children, but not related to cardiovascular diseaseen_US
dc.typeArticleen_US

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