Bubble column and airlift bioreactor systems for animal cell culture applications

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dc.authorscopusid57208883929
dc.authorscopusid23995769500
dc.contributor.authorMutaf, Tugce
dc.contributor.authorOncel, Suphi S.
dc.date.accessioned2023-01-12T19:49:38Z
dc.date.available2023-01-12T19:49:38Z
dc.date.issued2022
dc.departmentN/A/Departmenten_US
dc.description.abstractMany biopharmaceutical industries have focused on the screening for novel cell lines and producers for manufacturing of advanced therapeutics. Commercial scale productions at reduced cost and improved productivity are only possible with the bioreactor systems. Animal cell culture bioreactors have all started to draw attention in view that 20th century and advanced significantly over the previous few a long time especially with the need for viral vaccine productions, monoclonal antibody productions and in vitro meat productions. To produce these high value-added products in large scales, bioreactor configurations are advanced to reduce investment and operational costs, control the process parameters, enhance productivity, and make easier scale-up. Although novel bioreactor systems have interested in recent years, conventional bubble column and airlift systems are still the most familiar and experienced bioreactors. Pneumatically agitated bioreactors have been studied for many years in animal cell culture. This current review intends to provide an overview of pneumatic bioreactor productions for animal cell culture applications in key items of cell culture and bioreactor technology, for example, design parameters, transport phenomena during cultivation, shear sensitivity of cells. Besides, the previous studies, investigated that the design parameters and process conditions for productivity and shear sensitivity, have been reviewed and summarized.en_US
dc.identifier.doi10.1002/apj.2872
dc.identifier.issn1932-2135
dc.identifier.issn1932-2143
dc.identifier.issn1932-2135en_US
dc.identifier.issn1932-2143en_US
dc.identifier.scopus2-s2.0-85145281517en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.1002/apj.2872
dc.identifier.urihttps://hdl.handle.net/11454/75868
dc.identifier.wosWOS:000904807100001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofAsia-Pacific Journal Of Chemical Engineeringen_US
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectairlift bioreactoren_US
dc.subjectanimal cell cultureen_US
dc.subjectbioreactor designen_US
dc.subjectbubble column bioreactoren_US
dc.subjectscale-upen_US
dc.subjectAverage Shear Rateen_US
dc.subjectMass-Transferen_US
dc.subjectStirred-Tanken_US
dc.subjectMonoclonal-Antibodiesen_US
dc.subjectOxygenen_US
dc.subjectHydrodynamicsen_US
dc.subjectPerformanceen_US
dc.subjectDesignen_US
dc.subjectVirusen_US
dc.titleBubble column and airlift bioreactor systems for animal cell culture applicationsen_US
dc.typeReviewen_US

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