Bubble column and airlift bioreactor systems for animal cell culture applications
Küçük Resim Yok
Tarih
2022
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Wiley
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Many biopharmaceutical industries have focused on the screening for novel cell lines and producers for manufacturing of advanced therapeutics. Commercial scale productions at reduced cost and improved productivity are only possible with the bioreactor systems. Animal cell culture bioreactors have all started to draw attention in view that 20th century and advanced significantly over the previous few a long time especially with the need for viral vaccine productions, monoclonal antibody productions and in vitro meat productions. To produce these high value-added products in large scales, bioreactor configurations are advanced to reduce investment and operational costs, control the process parameters, enhance productivity, and make easier scale-up. Although novel bioreactor systems have interested in recent years, conventional bubble column and airlift systems are still the most familiar and experienced bioreactors. Pneumatically agitated bioreactors have been studied for many years in animal cell culture. This current review intends to provide an overview of pneumatic bioreactor productions for animal cell culture applications in key items of cell culture and bioreactor technology, for example, design parameters, transport phenomena during cultivation, shear sensitivity of cells. Besides, the previous studies, investigated that the design parameters and process conditions for productivity and shear sensitivity, have been reviewed and summarized.
Açıklama
Anahtar Kelimeler
airlift bioreactor, animal cell culture, bioreactor design, bubble column bioreactor, scale-up, Average Shear Rate, Mass-Transfer, Stirred-Tank, Monoclonal-Antibodies, Oxygen, Hydrodynamics, Performance, Design, Virus
Kaynak
Asia-Pacific Journal Of Chemical Engineering
WoS Q Değeri
Q3
Scopus Q Değeri
Q3
