EVect of lisinopril on renal tissue damage in unilateral ureteral obstruction in rats

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dc.contributor.authorKarabuga Ä.
dc.contributor.authorAkbay K.
dc.contributor.authorTurna B.
dc.contributor.authorVatansever H.S.
dc.contributor.authorAltay B.
dc.contributor.authorGüzel E.
dc.contributor.authorUluer E.T.
dc.contributor.authorUstun G.
dc.contributor.authorEkren F.
dc.contributor.authorNazli O.
dc.contributor.authorMuftuoglu S.
dc.contributor.authorApaydin E.
dc.date.accessioned2019-10-27T08:33:15Z
dc.date.available2019-10-27T08:33:15Z
dc.date.issued2012
dc.departmentEge Üniversitesien_US
dc.description.abstractIn this study, it was aimed to investigate apoptosis in renal injury and the eVect of lisinopril in rat model, which constitute unilateral ureteral obstruction. The retroperitoneal ureter was ligated with a 4.0 silk for the experimental model of ureteral obstruction in Wistar albino rats. Untreated group (n = 20) received no treatment. For the lisinopril-treated group (n = 20), 20 mg/kg/day of drug was given orally. Ultrastructural diVerences were analyzed using electron microscopic technique; apoptotic distribution was analyzed using the TUNEL method. After electron microscopic evaluation, on the 4th and 14th day in the untreated group, edema in the glomeruli, loss of microvillus and apoptotic cells in proximal tubule cells and sclerosis in the glomeruli were detected. On the 4th day in the lisinopril-treated group, the kidney was ultrastructurally normal and a less number of apoptotic cells were only observed on the 14th day. On light microscopic examination on the 4th and 14th day in the untreated group, while the glomeruli were normal in structure, the boundary of the proximal tubule was disrupted and some picnotic cells in both the proximal and collecting tubules were observed. In both 4th and 14th day of the lisinopril-treated group, kidney showed normal structure, although in some places picnotic cells in the collecting tubules were observed. In conclusion, lisinopril was eVective and it may prevent early renal damage in the direct obstruction model. © Springer-Verlag 2011.en_US
dc.identifier.doi10.1007/s00240-011-0393-7en_US
dc.identifier.endpage34en_US
dc.identifier.issn0300-5623
dc.identifier.issue1en_US
dc.identifier.pmid21667191en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage27en_US
dc.identifier.urihttps://doi.org/10.1007/s00240-011-0393-7
dc.identifier.urihttps://hdl.handle.net/11454/26708
dc.identifier.volume40en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofUrological Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectApoptosisen_US
dc.subjectLisinoprilen_US
dc.subjectRaten_US
dc.subjectRenal damageen_US
dc.subjectUreteral obstructionen_US
dc.titleEVect of lisinopril on renal tissue damage in unilateral ureteral obstruction in ratsen_US
dc.typeArticleen_US

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