Comparison of the effects of dietary saturated, mono-, and n-6 polyunsaturated fatty acids on blood lipid profile, oxidant stress, prostanoid synthesis and aortic histology in rabbits

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dc.contributor.authorBayindir, O
dc.contributor.authorOzmen, D
dc.contributor.authorMutaf, I
dc.contributor.authorTurgan, N
dc.contributor.authorHabif, S
dc.contributor.authorGulter, C
dc.contributor.authorParildar, Z
dc.contributor.authorUysal, AE
dc.date.accessioned2019-10-27T18:43:37Z
dc.date.available2019-10-27T18:43:37Z
dc.date.issued2002
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground/Aims: To compare the effects of saturated, monounsaturated and polyunsaturated n-6 fatty acid-enriched diets on the development of atherosclerosis and thrombosis in New Zealand white male rabbits, 3- to 6-month-old animals were supplemented daily (10 g/100 g diet) with butter (n = 8), olive oil (n = 8) or corn oil (n = 8) by oral administration for 7 weeks. Methods: Total cholesterol (TC), HDL- (HDL-C) and LDL-cholesterol (LDL-C), triglycerides (TG), apolipoprotein A-1 (ApoA-1), apolipoprotein B (ApoB), lipid peroxides as thiobarbituric acid-reactive substances (TBARS), thromboxane B2 (TXB2) and 6-ketoprostaglandin F-1alpha (6-ketoPGF(1alpha)) concentrations were determined in blood samples drawn before and after each group was fed the different dietary regimens. Histological examination was performed on the aortic tissues. Results: After 7 weeks, TC, ApoB and TXB2 increased significantly (p < 0.05) in the butter-fed animals compared to pre-experimental concentrations. Olive oil administration lead to a significant (p < 0.05) decrease in TC and ApoB levels. The corn oil-enriched diet decreased TC, LDL-C concentrations, TC/HDL-C ratios and 6-ketoPGF(1alpha) (stable metabolite of prostacyclin-PGI(2); p < 0.05 for all) but increased TBARS levels and TXB2/6-ketoPGF(1alpha) ratios. Light microscopic findings were in accordance with these biochemical alterations. Conclusion: Although effective in lipid lowering, corn oil increased oxidant stress as evidenced by increased TBARS and induced endothelial damage which lead to a reduction in PGI(2) synthesis and consequently to an increase in the TXB2/6-ketoPGF(1alpha) ratio. Olive oil administration did not induce oxidant stress and it had no affect on PGI(2) and TXB2 levels which are implicated in platelet aggregation. These findings suggest that oleic acid is more effective than linoleic acid in the protection of endothelial integrity.en_US
dc.identifier.doi10.1159/000065411en_US
dc.identifier.endpage228en_US
dc.identifier.issn0250-6807
dc.identifier.issue5en_US
dc.identifier.pmid12378047en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage222en_US
dc.identifier.urihttps://doi.org/10.1159/000065411
dc.identifier.urihttps://hdl.handle.net/11454/37234
dc.identifier.volume46en_US
dc.identifier.wosWOS:000178862700010en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofAnnals of Nutrition and Metabolismen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMediterranean dieten_US
dc.subjectoleic aciden_US
dc.subjectatherosclerosisen_US
dc.subjectoxidant stressen_US
dc.subjectlinoleic aciden_US
dc.subjectvasoactive prostanoidsen_US
dc.titleComparison of the effects of dietary saturated, mono-, and n-6 polyunsaturated fatty acids on blood lipid profile, oxidant stress, prostanoid synthesis and aortic histology in rabbitsen_US
dc.typeArticleen_US

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