The association between seizure predisposition and inflammation in a rat model of fatty liver disease

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dc.contributor.authorAksoy, Durdane
dc.contributor.authorSolmaz, Volkan
dc.contributor.authorTaskiran, Dilek
dc.contributor.authorErbas, Oytun
dc.date.accessioned2019-10-27T22:13:33Z
dc.date.available2019-10-27T22:13:33Z
dc.date.issued2014
dc.departmentEge Üniversitesien_US
dc.description.abstractThe association between inflammation and the induction of seizures is well-known. It has been reported that non-alcoholic fatty liver disease (NAFLD) is associated with a pro-inflammatory state, and systemic inflammation may trigger central nervous system inflammation. This study aims to identify the impact of inflammation in a rat model of fatty liver on the propensity and severity of pentylenetetrazol (PTZ)-induced seizures. Twenty-four male Sprague-Dawley rats were divided into four groups. Groups 1 and 2 were administered a 35 % fructose solution over 8 weeks to induce the development of fatty liver while Groups 3 and 4 were fed normally as controls. Groups 1 and 3 were given 70 mg/kg PTZ, determining Racine Convulsion Scores (RCS) and onset times of the first myoclonic jerks (FMJ). Groups 2 and 4 were administered 35 mg/kg of PTZ, then EEG recordings were obtained to evaluate spike percentages. TNF-alpha levels in brain and liver tissues were also measured. While RCS's of fatty liver rats were higher than the control group (p > 0.05) as well as spike percentages (p < 0.05), FMJ onset time was significantly shorter. TNF-alpha levels in liver and brain tissues of the rats with NAFLD were significantly higher than the control rats. We found that rats with NAFLD demonstrated decreased seizure thresholds, possibly due to increased cytokine levels systemically and within the central nervous system. As such, epilepsy patients taking medications that may predispose the development of NAFLD must be carefully managed to prevent the possibility of increased seizure episodes.en_US
dc.identifier.doi10.1007/s10072-014-1778-5en_US
dc.identifier.endpage1446en_US
dc.identifier.issn1590-1874
dc.identifier.issn1590-3478
dc.identifier.issue9en_US
dc.identifier.pmid24715054en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1441en_US
dc.identifier.urihttps://doi.org/10.1007/s10072-014-1778-5
dc.identifier.urihttps://hdl.handle.net/11454/49819
dc.identifier.volume35en_US
dc.identifier.wosWOS:000342123300016en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer-Verlag Italia Srlen_US
dc.relation.ispartofNeurological Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEpilepsyen_US
dc.subjectNon-alcoholic fatty liver diseaseen_US
dc.subjectInflammationen_US
dc.subjectTNF-alphaen_US
dc.titleThe association between seizure predisposition and inflammation in a rat model of fatty liver diseaseen_US
dc.typeArticleen_US

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