The actin-bundling protein L-plastin: a novel local inflammatory marker associated with periodontitis

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dc.contributor.authorOzturk, V. O.
dc.contributor.authorEmingil, G.
dc.contributor.authorOsterwalder, V.
dc.contributor.authorBostanci, N.
dc.date.accessioned2019-10-27T23:00:21Z
dc.date.available2019-10-27T23:00:21Z
dc.date.issued2015
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground and ObjectiveL-plastin, an actin-bundling protein, is exclusively expressed in leukocytes and plays a crucial role in immune-mediated events. Periodontitis is a common infectious inflammatory disease that destroys the tooth-supporting tissues. Recent findings using proteomic technologies have demonstrated that L-plastin is one of the few molecules consistently present in the inflammatory exudate of the gingiva in periodontal disease, but not in health. Therefore, this study aimed to investigate in detail the local and systemic role of this molecule in different forms of periodontitis. Material and MethodsA total of 61 subjects who met the inclusion/exclusion criteria were recruited, including 21 with chronic periodontitis, 20 generalized aggressive periodontitis and 20 nonperiodontitis control subjects. Gingival tissue biopsies, gingival crevicular fluid, as well as serum and saliva, were obtained. Immunohistochemistry and quantitative real-time PCR were employed to evaluate the localization and mRNA expression, respectively, of L-plastin. L-plastin levels in gingival crevicular fluid, saliva and serum were measured using ELISA. Statistical analysis was performed using nonparametric methods. ResultsSubjects with chronic periodontitis and generalized aggressive periodontitis exhibited significantly higher tissue L-plastin gene expression and gingival crevicular fluid levels than did subjects in the control group but there was no significant difference between the two forms of periodontitis. Within gingival tissue, L-plastin was confined to the inflammatory infiltrate. There was no statistically significant difference between serum and salivary L-plastin levels among the three study groups. ConclusionThe elevated gingival tissue expression and gingival crevicular fluid levels of L-plastin in both forms of periodontitis may denote the localized involvement of this novel molecule in the pathogenesis of the disease.en_US
dc.description.sponsorshipCED IADR Visiting Fellowship Granten_US
dc.description.sponsorshipThis study was supported by the Authors' Institutes and a CED IADR Visiting Fellowship Grant (to V. O. O.). The funders had no role in study design, data collection and analysis, decision to publish or preparation of the article.en_US
dc.identifier.doi10.1111/jre.12212en_US
dc.identifier.endpage346en_US
dc.identifier.issn0022-3484
dc.identifier.issn1600-0765
dc.identifier.issue3en_US
dc.identifier.pmid25040533en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage337en_US
dc.identifier.urihttps://doi.org/10.1111/jre.12212
dc.identifier.urihttps://hdl.handle.net/11454/51985
dc.identifier.volume50en_US
dc.identifier.wosWOS:000353513000006en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Periodontal Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectgingivaen_US
dc.subjectgingival crevicular fluiden_US
dc.subjectinflammationen_US
dc.subjectL-plastinen_US
dc.subjectperiodontitisen_US
dc.subjectsalivaen_US
dc.subjectserumen_US
dc.titleThe actin-bundling protein L-plastin: a novel local inflammatory marker associated with periodontitisen_US
dc.typeArticleen_US

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