Adefovir treatment in posttransplant hepatitis B virus infection resistant to lamivudine plus hepatitis B virus immunoglobulin

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dc.contributor.authorAkay S.
dc.contributor.authorKarasu Z.
dc.contributor.authorAkyildiz M.
dc.contributor.authorTokat Y.
dc.date.accessioned2019-10-27T00:13:03Z
dc.date.available2019-10-27T00:13:03Z
dc.date.issued2004
dc.departmentEge Üniversitesien_US
dc.description.abstractFailure of prophylaxis for hepatitis B virus (HBV) recurrence in liver transplant patients with HBV immunoglobulin (HBIG) or lamivudine or both can be associated with rapid development of liver failure. Some of these patients develop a devastating clinicopathological state characterized by jaundice and rapidly progressive liver failure or fibrosing cholestatic hepatitis. We present two liver transplant recipients who experienced HBV recurrence while they were under lamivudine and HBIG prophylaxis. One of them had finding of severe HBV infection; the other, fibrosing cholestatic hepatitis. After commencing adefovir dipivoxil both patients showed improvements in clinical status and laboratory data. At month 4 of treatment, HBV DNA values became negative and liver function tests almost normalized. In addition, in one case showed HBs ag/anti-HBs seroconversion. When failure of prophylaxis with lamivudine and HBIG occurs, adefovir dipivoxil should be considered to be a safe and effective choice for recurrent HBV infections in liver transplant patients.en_US
dc.identifier.doi10.1016/j.transproceed.2004.09.062en_US
dc.identifier.endpage2770en_US
dc.identifier.issn0041-1345
dc.identifier.issue9en_US
dc.identifier.pmid15621144en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage2768en_US
dc.identifier.urihttps://doi.org/10.1016/j.transproceed.2004.09.062
dc.identifier.urihttps://hdl.handle.net/11454/22417
dc.identifier.volume36en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofTransplantation Proceedingsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleAdefovir treatment in posttransplant hepatitis B virus infection resistant to lamivudine plus hepatitis B virus immunoglobulinen_US
dc.typeArticleen_US

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