Early Onset Schizophrenia Associated With Obsessive-Compulsive Disorder: Clinical Features and Correlates
Küçük Resim Yok
Tarih
2017
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Lippincott Williams & Wilkins
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objectives Obsessive-compulsive disorder (OCD) is notably a comorbid disorder in patients with schizophrenia. This study aimed to evaluate clinical features and correlates of early onset patients with schizophrenia with OCD. Methods In the present study, we included 10 patients with both schizophrenia and OCD and 19 patients with schizophrenia without OCD. The mean antipsychotic doses the patients needed for treatment are standardized as chlorpromazine equivalent dose. Results The mean antipsychotic doses at first episode were 491 376 mg/d in schizophrenia comorbid OCD group and 290 +/- 209 mg/d in the schizophrenia without OCD group (P = 0.018). This significant difference was also found for the mean doses at the assessment for the study (512.40 +/- 336.22 mg/d in schizophrenia comorbid OCD and 296.05 +/- 147.25 mg/d in patients with schizophrenia without OCD, P = 0.012). There was no statistical difference in the mean scores of Clinical Global Impression and Positive and Negative Syndrome Scale between schizophrenia with and without OCD group, respectively. (Clinical Global Impression: 5 +/- 0.66 vs 4.36 +/- 0.83, P = 0.094; Positive and Negative Syndrome Scale: 67.60 +/- 11.84 vs 69.84 +/- 14.62, P = 0.573). Conclusions Adolescents with schizophrenia and OCD needed more antipsychotic doses for acute exacerbation and the maintenance of reduction of psychosis severity than adolescents with only schizophrenia. We could suggest that OCD comorbidity in schizophrenia is more treatment resistant, although the severity of the schizophrenia was similar between study groups. There was no correlation between OCD and schizophrenia symptoms either.
Açıklama
Anahtar Kelimeler
obsessive-compulsive disorder, schizophrenia, comorbidity, child, adolescent
Kaynak
Clinical Neuropharmacology
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
40
Sayı
6
