An autoimmune disease refractory to immunosuppressive regimens: Celiac disease diagnosed long after liver transplantation

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dc.contributor.authorEcevit, Cigdem
dc.contributor.authorKarakoyun, Miray
dc.contributor.authorUnal, Fatih
dc.contributor.authorYuksekkaya, Hasan A.
dc.contributor.authorDoganavsargil, Basak
dc.contributor.authorYagci, Rasit V.
dc.contributor.authorAydogdu, Sema
dc.date.accessioned2019-10-27T22:07:26Z
dc.date.available2019-10-27T22:07:26Z
dc.date.issued2013
dc.departmentEge Üniversitesien_US
dc.description.abstractCD is defined as T-lymphocyte-mediated gluten sensitivity. Although CD is known to affect the small intestine, it is nonetheless a multisystem disorder. Liver involvement in CD may vary from isolated hypertransaminasemia to cirrhosis. Because CD is an inappropriate immune response to gluten proteins, strict gluten-free diet is the principal therapy, along with management of liver dysfunction. In patients who fail to respond to a gluten-free diet, immunosuppressive drugs may improve intestinal inflammatory activity in untreated CD. The present case report is of a 25-yr-old woman with diarrhea lasting several weeks. The patient had received a liver transplant 13yr earlier, and presented with cryptogenic cirrhosis diagnosed as CD. This appears to be the first case of its kind in which a pediatric long-term liver transplant patient presents with diarrhea eventually diagnosed as CD whose diet included gluten, and who was treated by an immunosuppressive drug regimen. Because of the normalization of CD-related antibodies in the post-transplantation period without gluten restriction, CD should be part of a list of diagnostic possibilities in liver transplant patients presenting with diarrhea of unknown etiology.en_US
dc.identifier.doi10.1111/petr.12136en_US
dc.identifier.endpageE160en_US
dc.identifier.issn1397-3142
dc.identifier.issn1399-3046
dc.identifier.issue7en_US
dc.identifier.pmid23962034en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpageE156en_US
dc.identifier.urihttps://doi.org/10.1111/petr.12136
dc.identifier.urihttps://hdl.handle.net/11454/49013
dc.identifier.volume17en_US
dc.identifier.wosWOS:000325369400002en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofPediatric Transplantationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectceliac diseaseen_US
dc.subjectimmunosuppressive therapyen_US
dc.subjectliver transplantationen_US
dc.titleAn autoimmune disease refractory to immunosuppressive regimens: Celiac disease diagnosed long after liver transplantationen_US
dc.typeArticleen_US

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