Association of mannose binding lectin codon 54 polymorphism with predisposition to Henoch-Schönlein purpura in childhood

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dc.contributor.authorDurmaz B.
dc.contributor.authorAykut A.
dc.contributor.authorHursitoglu G.
dc.contributor.authorBak M.
dc.contributor.authorSerdaroglu E.
dc.contributor.authorOnay H.
dc.contributor.authorÖzkınay F.
dc.date.accessioned2019-10-27T08:22:36Z
dc.date.available2019-10-27T08:22:36Z
dc.date.issued2014
dc.departmentEge Üniversitesien_US
dc.description.abstractAim: Immune and inflammatory response activation is a common feature of systemic vasculitis. There is a protein called mannose binding lectin (MBL) that was reported to play an important role in innate immunity. MBL polymorphisms in the MBL gene cause predisposition to infectious and autoimmune diseases. There is no study in the literature investigating the association between MBL polymorphisms and Henoch-Schönlein purpura (HSP) to date. Therefore, the aim of this study is to determine the presence of any association between MBL gene variants and HSP in a child population. Method: Codon 54 polymorphism in exon 1 of the MBL gene was investigated by polymerase chain reaction - restriction fragment length polymorphism method in 100 children diagnosed as having HSP and 100 age-matched healthy controls. Results: The mutant B allele frequency was not significantly higher in the patient group (16%) compared to the control group (14%). AB genotype was found to be 28% and 26% in the patient group and healthy control group, respectively. AA genotype was found in 70% of the children with HSP and 73% of the healthy control group. Conclusion: These results suggest that codon 54 polymorphism in the MBL gene may hardly play a role in susceptibility to HSP in children, the first time this has been reported in the literature. © 2014 Asia Pacific League of Associations for Rheumatology and Wiley Publishing Asia Pty Ltd.en_US
dc.identifier.doi10.1111/1756-185X.12321en_US
dc.identifier.endpage320en_US
dc.identifier.issn1756-1841
dc.identifier.issue3en_US
dc.identifier.pmid24576294en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage317en_US
dc.identifier.urihttps://doi.org/10.1111/1756-185X.12321
dc.identifier.urihttps://hdl.handle.net/11454/26282
dc.identifier.volume17en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBlackwell Publishingen_US
dc.relation.ispartofInternational Journal of Rheumatic Diseasesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHenoch-Schönlein purpuraen_US
dc.subjectMannose binding lectinen_US
dc.subjectPolymorphismen_US
dc.titleAssociation of mannose binding lectin codon 54 polymorphism with predisposition to Henoch-Schönlein purpura in childhooden_US
dc.typeArticleen_US

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