The Disrupted Connection Between Cerebral Hemispheres in Schizophrenia Patients: A Diffusion Tensor Imaging Study

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dc.contributor.authorKitis, Omer
dc.contributor.authorEker, M. Cagdas
dc.contributor.authorZengin, Burcak
dc.contributor.authorAkyilmaz, Dincer Aydin
dc.contributor.authorYalvac, Dilek
dc.contributor.authorOzdemir, Halil Ibrahim
dc.contributor.authorHaznedaroglu, Damla Isman
dc.contributor.authorBilgi, Mustafa Melih
dc.contributor.authorGonul, Ali Saffet
dc.date.accessioned2019-10-27T21:35:10Z
dc.date.available2019-10-27T21:35:10Z
dc.date.issued2011
dc.departmentEge Üniversitesien_US
dc.description.abstractAim: In schizophrenia, the disruption of the communication between two brain hemispheres has not been shown clearly in the anatomical aspect despite other studies with different modalities suggested so. In this study, the structural integrity and the variables affecting the structural integrity of the corpus callosum, which is the main connection between two hemispheres, was investigated via diffusion tensor imaging (DTI). Methods: The participants were evaluated by SCID-I and symptoms of the patients were assessed with PANSS. DT images of 25 schizophrenia patients and 17 healthy volunteers were acquired via 1.5 T MR. Fractioned Anisotropy (FA) values of two groups, measured on the DT images, were compared. Results: It was found that fractioned anisotropy (FA) values were lower in the genu of the patients than the healthy controls; however, there was no difference between the FA values of the patients and the controls in the splenium. Moreover, a significant negative correlation between the splenium FA values and the antipsychotic medication doses; and a trend level negative correlation of splenium FA and PANSS scores were found. Conclusion: Corpus callosum is the most important structure that connects two frontal lobes. The hypothesis that posits the fundamental role of the disconnection of frontal lobes in schizophrenia is supported by the findings of this study.en_US
dc.identifier.endpage221en_US
dc.identifier.issn1300-2163
dc.identifier.issue4en_US
dc.identifier.pmid22143946en_US
dc.identifier.startpage213en_US
dc.identifier.urihttps://hdl.handle.net/11454/45794
dc.identifier.volume22en_US
dc.identifier.wosWOS:000299187000003en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isotren_US
dc.publisherTurkiye Sinir Ve Ruh Sagligi Dernegien_US
dc.relation.ispartofTurk Psikiyatri Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSchizophreniaen_US
dc.subjectcorpus callosumen_US
dc.subjectdiffusion tensor imagingen_US
dc.subjectconnectivityen_US
dc.subjectpositive and negative symptoms scale (PANSS)en_US
dc.titleThe Disrupted Connection Between Cerebral Hemispheres in Schizophrenia Patients: A Diffusion Tensor Imaging Studyen_US
dc.typeArticleen_US

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