Impedimetric detection of in situ interaction between anti-cancer drug bleomycin and DNA
Küçük Resim Yok
Tarih
2013
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier Science Bv
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Surface confined interaction of anti-cancer drug bleomycin (BLM) with nucleic acids: single stranded and double stranded DNA was investigated herein by using electrochemical impedance spectroscopy (EIS) technique in combination with a graphite sensor technology. The experimental conditions were optimized: such as, dsDNA concentration, BLM concentration and interaction time. The main features of impedimetric DNA biosensor, such as its detection limit and the repeatability, were also discussed. The in situ interaction of BLM with dsDNA was also tested impedimetrically in the absence or presence of other chemotherapeutic agents, such as mitomycin C (MC) and cis-platin (cis-DDP) for testing the selectivity. (C) 2013 Elsevier B.V. All rights reserved.
Açıklama
Anahtar Kelimeler
Bleomycin, Drug-DNA interactions, Electrochemical impedance spectroscopy, Mitomycin C, Cis-platin
Kaynak
International Journal of Biological Macromolecules
WoS Q Değeri
Q2
Scopus Q Değeri
Q1
Cilt
61
