Effects of metoclopramide and ranitidine on survival of flat template McFarlane skin flaps in a rat wound healing model

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dc.contributor.authorYilmaz Dilsiz O.
dc.contributor.authorAkhundzada I.
dc.contributor.authorBilkay U.
dc.contributor.authorUyanikgil Y.
dc.contributor.authorTeymur H.
dc.contributor.authorAtes U.
dc.contributor.authorBaka M.
dc.date.accessioned2019-10-26T21:28:06Z
dc.date.available2019-10-26T21:28:06Z
dc.date.issued2014
dc.departmentEge Üniversitesien_US
dc.description.abstractWound healing re-provides the morphological integrity after trauma. We investigated the effects of Metoclopramide and Ranitidine on survival of flat template McFarlane skin flaps in an experimental wound healing model. Rats (n:32) were randomly allocated in following groups: Flap control (Control), Metoclopramide(MET), Ranitidine(RAN) and Metoclopramide+Ranitidine (MET+RAN). After flap elevation, ip 10 mg/kg Ranitidin or 5 mg/kg Metoclopramide or the combination of both drugs were administered for 3 days. Next analgesia was maintained. No additional drugs were used for controls. On 10th day, whole cut skin flaps were excised, fixed in buffered formaldehyde and processed with histological techniques. Paraffine sections were stained with Hematoxylen-Eosin, Mallory-Azan and immunohistochemically with Desmin and Fibronectin and then evaluated with light microscopy. Experimental groups showed differences for epidermal degeneration, edema, hypertrophy of the hair follicles, neutrophil infiltration and areolar degeneration. Metoclopramide or Ranitidine administration positively impacts wound healing. This unique study emphasizes the importance of considering Metoclopramide or Ranitidine for possible adverse effects on flap survival in surgical clinics, therefore the combination of both drugs is not more effective. © Georg Thieme Verlag KG Stuttgart, New York.en_US
dc.identifier.doi10.1055/s-0033-1353180en_US
dc.identifier.endpage97en_US
dc.identifier.issn2194-9379
dc.identifier.issue2en_US
dc.identifier.pmid24026958en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage91en_US
dc.identifier.urihttps://doi.org/10.1055/s-0033-1353180
dc.identifier.urihttps://hdl.handle.net/11454/17461
dc.identifier.volume64en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofDrug Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjecthistologyen_US
dc.subjectimmunohistochemistryen_US
dc.subjectmetoclopramideen_US
dc.subjectplastic surgeryen_US
dc.subjectranitidineen_US
dc.titleEffects of metoclopramide and ranitidine on survival of flat template McFarlane skin flaps in a rat wound healing modelen_US
dc.typeArticleen_US

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