Preparation and evaluation of novel microemulsion-based hydrogels for dermal delivery of benzocaine

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dc.contributor.authorOkur, Neslihan Ustundag
dc.contributor.authorCaglar, Emre Sefik
dc.contributor.authorArpa, Muhammet Davut
dc.contributor.authorKarasulu, H. Yesim
dc.date.accessioned2019-10-27T11:08:00Z
dc.date.available2019-10-27T11:08:00Z
dc.date.issued2017
dc.departmentEge Üniversitesien_US
dc.description.abstractThe purpose of the current research was to prepare and evaluate the potential use of microemulsion-based hydrogel (MBH) formulations for dermal delivery of benzocaine (BZN). The pseudoternary-phase diagrams were constructed for various microemulsions composed of isopropyl myristate (IPM) as oil phase, Span 20, Tween 20, Tween 80, cremophor EL and cremophor RH40 as surfactants, ethanol as cosurfactant and distilled water as aqueous phase. Finally, concentration of BZN in microemulsions was 2% (w/w). The physicochemical properties, such as conductivity, viscosity, pH, droplet size, polydispersity index and zeta potential of microemulsions, were measured. Carbopol 940 was used to convert BZN-loaded microemulsions into gel form without affecting their structure. Furthermore, excised rat abdominal skin was used to compare permeation and penetration properties of BZN loaded M3 and M3BHs with BZN solution. According to ex vivo study results, BZN-loaded M3BH1 showed highest flux values and high release rate values, and furthermore, this gel formulation had low surfactant content. Finally, in order to learn the localization of formulations within the dermal penetration, formulations and BZN solution were labeled with red oil O and subjected to fluorescence observation. In conclusion, BZN-loaded MBHs could be offered as a promising strategy for dermal drug delivery.en_US
dc.description.sponsorshipIstanbul Medipol University, Scientific Research Projects [2015/17]en_US
dc.description.sponsorshipThis study was supported by Istanbul Medipol University, Scientific Research Projects No: 2015/17.en_US
dc.identifier.doi10.3109/10837450.2015.1131716en_US
dc.identifier.endpage510en_US
dc.identifier.issn1083-7450
dc.identifier.issn1097-9867
dc.identifier.issue4en_US
dc.identifier.pmid26738443en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage500en_US
dc.identifier.urihttps://doi.org/10.3109/10837450.2015.1131716
dc.identifier.urihttps://hdl.handle.net/11454/32110
dc.identifier.volume22en_US
dc.identifier.wosWOS:000399500700007en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofPharmaceutical Development and Technologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBenzocaineen_US
dc.subjectdermal drug deliveryen_US
dc.subjectcharacterizationen_US
dc.subjectfluorescence observationen_US
dc.subjectmicroemulsionen_US
dc.subjectmicroemulsion-based hydrogelen_US
dc.titlePreparation and evaluation of novel microemulsion-based hydrogels for dermal delivery of benzocaineen_US
dc.typeArticleen_US

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