Association of TNF-? -308 polymorphism with the outcome of hepatitis B virus infection in Turkey

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dc.contributor.authorBasturk B.
dc.contributor.authorKarasu Z.
dc.contributor.authorKilic M.
dc.contributor.authorUlukaya S.
dc.contributor.authorBoyacioglu S.
dc.contributor.authorOral B.
dc.date.accessioned2019-10-27T08:36:55Z
dc.date.available2019-10-27T08:36:55Z
dc.date.issued2008
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground and aim: Cytokines play important roles in the regulation of immune response. The aim of the study was to investigate the association of the cytokine gene polymorphisms with persistence of hepatitis B virus (HBV) infection and the development of end-stage liver disease (ESLD) due to HBV infection. Methods: The study involved 27 patients with end-stage liver disease due to HBV infection, 23 HBV carriers and 60 healthy controls. All genotyping (TNF-?, TGF-ß, IL-10, IFN-?) experiments were performed using sequence specific primers (PCR-SSP) by using commercial kit according to manufacturers' instructions. Results: The frequencies of TNF-? -308 G/G and TGF-ß1 codon 10-25 T/C-G/G polymorphisms were significantly higher in HBV-infected individuals (patients + carriers) when compared with those of healthy controls (p: 0.02 and p: 0.004, respectively). The frequency of TNF-? -308 G/G polymorphism was significantly higher in the patients than those of the healthy controls (p: 0.02), whereas the frequency of TGF-ß1 codon 10-25 T/T-G/G polymorphism was lower (p: 0.028). On the other hand, TNF-? -308 G/G and TGF-ß codon 10-25 T/C-G/G polymorphisms were significantly more common in HBV carriers than the control group (p: 0.017 and p: 0.018, respectively). In addition, TNF-? -308 G allele frequency was significantly more common in HBV-infected individuals (patients + carriers) than those of healthy controls (p: 0.0007). TNF-? -308 G allele frequency was also found to be higher in patients or carriers when compared with those of healthy controls (p: 0.01 and p: 0.01, respectively). Statistically significant differences were still kept after Bonferroni correction of the p-values for only TNF-? -308 G allele frequency in patients or carriers (Pc). Conclusion: Our study suggests that TNF-? gene polymorphism in patients infected with HBV would result in relatively inefficient inhibition of HBV and development of ESLD, and therefore, may be valuable predictor determinants for the development of ESLD in patients with chronic HBV infection. © 2007 Elsevier B.V. All rights reserved.en_US
dc.identifier.doi10.1016/j.meegid.2007.09.001en_US
dc.identifier.endpage25en_US
dc.identifier.issn1567-1348
dc.identifier.issue1en_US
dc.identifier.pmid17974504en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage20en_US
dc.identifier.urihttps://doi.org/10.1016/j.meegid.2007.09.001
dc.identifier.urihttps://hdl.handle.net/11454/27459
dc.identifier.volume8en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofInfection, Genetics and Evolutionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCytokinesen_US
dc.subjectGene polymorphismsen_US
dc.subjectHepatic failureen_US
dc.subjectHepatitis Ben_US
dc.titleAssociation of TNF-? -308 polymorphism with the outcome of hepatitis B virus infection in Turkeyen_US
dc.typeArticleen_US

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