Examination of the Association between 3,4-Divanillyltetrahydrofuran Lignan (Urtica dioica Origin) and Prostate Cancer Cells by 131I Radiolabeling

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dc.authorscopusid56072334000
dc.authorscopusid56278104400
dc.authorscopusid10739428000
dc.authorscopusid57192664561
dc.contributor.authorTekin V.
dc.contributor.authorGuldu O.K.
dc.contributor.authorMedine E.I.
dc.contributor.authorMuftuler F.Z.B.
dc.date.accessioned2023-01-12T20:23:11Z
dc.date.available2023-01-12T20:23:11Z
dc.date.issued2021
dc.departmentN/A/Departmenten_US
dc.description.abstractBackground: Prostate cancer is the most common type of cancer for men in many countries. One of the various prostate cancer therapy methods is hormone therapy, and explaining the association between androgen hormones and prostate cancer is a critical role for successful prostate cancer treatment. Materials and Methods: In the current study, the behavior of 3,4-divanillyltetrahydrofuran (DTH) was examined against prostate cancer cells, which have androgen sensitivity differences [LNCaP (+), PC3 (-)]. For this aim, DTH was obtained by extraction of Urtica dioica roots. The molecular structure of isolated compound was confirmed as DTH by liquid chromatography-mass spectrometry and nuclear magnetic resonance spectroscopy analyses. To evaluate the association of androgen sensitivity, DTH was radiolabeled with 131I, and cell uptake assay was performed by using 131I-radiolabeled DTH. Also, cytotoxicity (WST-1) assay of DTH was performed against LNCaP and PC3 cells to determinate the toxic effects of DTH on different androgen mechanisms. Results: The results of assays on cells have shown that DTH lignan behaves different like being more toxic to LNCaP cells than PC3 cells, depending on androgen sensitivity. Conclusion: The results may contribute both the research topics of phytolignan prostate cancer and androgen-sensitive prostate cancer. © 2021, Mary Ann Liebert, Inc., publishers.en_US
dc.description.sponsorshipThe authors are thankful to PhD student Talha Siddik Akkaya for supporting to obtain stinging nettle plant.en_US
dc.identifier.doi10.1089/cbr.2020.3602
dc.identifier.endpage332en_US
dc.identifier.issn1084-9785
dc.identifier.issue4en_US
dc.identifier.pmid32453606en_US
dc.identifier.scopus2-s2.0-85106494208en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage326en_US
dc.identifier.urihttps://doi.org/10.1089/cbr.2020.3602
dc.identifier.urihttps://hdl.handle.net/11454/79655
dc.identifier.volume36en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMary Ann Liebert Inc.en_US
dc.relation.ispartofCancer Biotherapy and Radiopharmaceuticalsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject3,4-divanilylltetrahydrofuranen_US
dc.subjectLNCaPen_US
dc.subjectPC3en_US
dc.subjectUrtica dioicaen_US
dc.subject3,4 divanillyltetrahydrofuran i 131en_US
dc.subjectandrogenen_US
dc.subjectcelluloseen_US
dc.subjectlignanen_US
dc.subjecttetrahydrofuran derivativeen_US
dc.subjecttraceren_US
dc.subjectunclassified drugen_US
dc.subjectArticleen_US
dc.subjectcancer therapyen_US
dc.subjectcastration sensitive prostate canceren_US
dc.subjectchemical reactionen_US
dc.subjectchemical structureen_US
dc.subjectclinical evaluationen_US
dc.subjectcontrolled studyen_US
dc.subjectcytotoxicityen_US
dc.subjectdisease associationen_US
dc.subjectdrug isolationen_US
dc.subjecthigh performance liquid chromatographyen_US
dc.subjecthumanen_US
dc.subjecthuman cellen_US
dc.subjectLNCaP cell lineen_US
dc.subjectmaleen_US
dc.subjectnuclear magnetic resonance spectroscopyen_US
dc.subjectplant rooten_US
dc.subjectpriority journalen_US
dc.subjectprostate adenocarcinoma cell lineen_US
dc.subjectprostate canceren_US
dc.subjectprostate cancer cell lineen_US
dc.subjectradioactivityen_US
dc.subjectradiochromatographyen_US
dc.subjectradiolabelingen_US
dc.subjecttoxicity testingen_US
dc.subjectuptake assayen_US
dc.subjectUrtica dioicaen_US
dc.subjectWST-1 assayen_US
dc.subjectchemistryen_US
dc.subjectproceduresen_US
dc.subjectprostate tumoren_US
dc.subjectradioimmunoassayen_US
dc.subjectUrtica dioicaen_US
dc.subjectHumansen_US
dc.subjectMaleen_US
dc.subjectProstatic Neoplasmsen_US
dc.subjectRadioimmunodetectionen_US
dc.subjectUrtica dioicaen_US
dc.titleExamination of the Association between 3,4-Divanillyltetrahydrofuran Lignan (Urtica dioica Origin) and Prostate Cancer Cells by 131I Radiolabelingen_US
dc.typeArticleen_US

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