Reflections of the sensory findings in the central nervous system in patients with neuropathic pain

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dc.authoridkoken, idris şevki/0000-0001-5993-8579
dc.authorscopusid57203750584
dc.authorscopusid6508142604
dc.authorscopusid57202468538
dc.authorscopusid57201307584
dc.authorscopusid12769996400
dc.authorwosidkoken, idris şevki/HJH-0267-2022
dc.contributor.authorTanigor, Goksel
dc.contributor.authorHepguler, Simin
dc.contributor.authorKoken, Idris
dc.contributor.authorCalli, Mehmet Cem
dc.contributor.authorUyar, Meltem
dc.date.accessioned2023-01-12T19:50:04Z
dc.date.available2023-01-12T19:50:04Z
dc.date.issued2022
dc.departmentN/A/Departmenten_US
dc.description.abstractThis study aimed to evaluate whether there was a difference in functional magnetic resonance imaging (fMRI) findings in patients who were found having hyperalgesia or hypoesthesia according to Quantitative Sensory Tests (QST). Forty participants were included in the study: 20 with neuropathic pain (NP) due to cervical disc pathology (NP group) and 20 healthy volunteers. After obtaining the socio-demographic and clinical data of the participants, the painDETECT questionnaire was administered, followed by QST analysis to show the presence of hypoesthesia and/or hyperalgesia, and fMRI examinations, which included sensory stimulation of both extremities. Sensory threshold tests were found to be higher in the NP group compared with the healthy volunteers, and the heat pain threshold was found to be lower in the tests showing pain thresholds in the intergroup analyses (p < 0.05). The changes described were found in both painful and non-painful limbs. In the hypoesthetic NP group, a lower somatosensory cortex activity was found in non-painful limbs compared with the healthy volunteers (p < 0.05). In the unilateral hyperalgesic NP group, a lower somatosensory cortex activity was found on the painful side, and if the hyperalgesia was widespread, lower blood oxygen-level-dependent activity was also found in the operculum and insular cortex (p < 0.05). The patients with different phenotypes of NP had different activities in the areas related to the processing of pain, and were more prominent in patients with widespread hyperalgesia. Studies with larger numbers of patients are required for a definite statement.en_US
dc.description.sponsorshipEge University Research Projects Committee [TTU-2019-20708]en_US
dc.description.sponsorshipThis study was funded by Ege University Research Projects Committee (grant number: TTU-2019-20708).en_US
dc.identifier.doi10.1007/s00221-022-06315-9
dc.identifier.endpage1091en_US
dc.identifier.issn0014-4819
dc.identifier.issn1432-1106
dc.identifier.issue4en_US
dc.identifier.pmid35113193en_US
dc.identifier.scopus2-s2.0-85124144787en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1081en_US
dc.identifier.urihttps://doi.org/10.1007/s00221-022-06315-9
dc.identifier.urihttps://hdl.handle.net/11454/76006
dc.identifier.volume240en_US
dc.identifier.wosWOS:000751677300001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofExperimental Brain Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNeuropathic painen_US
dc.subjectCervical radiculopathyen_US
dc.subjectFunctional magnetic resonance imagingen_US
dc.subjectSensory phenotypesen_US
dc.subjectQuantitative sensory testingen_US
dc.subjectGray-Matteren_US
dc.subjectBrainen_US
dc.subjectFmrien_US
dc.subjectMechanismsen_US
dc.subjectCortexen_US
dc.subjectQuestionnaireen_US
dc.subjectModulationen_US
dc.subjectActivationen_US
dc.subjectPaindetecten_US
dc.subjectPlasticityen_US
dc.titleReflections of the sensory findings in the central nervous system in patients with neuropathic painen_US
dc.typeArticleen_US

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