The clues in solving the mystery of major psychosis: the epigenetic basis of schizophrenia and bipolar disorder

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dc.contributor.authorGurel, Cevik
dc.contributor.authorKuscu, Gokce Ceren
dc.contributor.authorYavasoglu, Altug
dc.contributor.authorAvci, Cigir Biray
dc.date.accessioned2020-12-01T12:01:10Z
dc.date.available2020-12-01T12:01:10Z
dc.date.issued2020
dc.departmentEge Üniversitesien_US
dc.description.abstractSchizophrenia (SZ) and bipolar disorder (BD) are severe psychiatric diseases that are characterized by abnormalities of thought, behaviour, cognition and mood. the genetic findings obtained from past molecular genetics research failed to elucidate the molecular pathogenesis of SZ and BD and this situation showed that the risk factors for these diseases were not solely due to the DNA sequence. on the other hand, evidence from cell, animal and postmortem brain studies suggest that abnormal epigenetic mechanisms are important actors in the etiology of complex diseases such as SZ and BD. in this review, epigenetic evidences that obtained from DNA methylation, post-translational histone modifications and non-coding RNA studies in SZ and BD were summarized and the importance of this evidences for advances in the diagnosis and treatment of SZ and BD were discussed briefly.en_US
dc.identifier.doi10.1016/j.neubiorev.2020.03.005en_US
dc.identifier.endpage61en_US
dc.identifier.issn0149-7634
dc.identifier.issn1873-7528
dc.identifier.pmid32147531en_US
dc.identifier.scopus2-s2.0-85081269977en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage51en_US
dc.identifier.urihttps://doi.org/10.1016/j.neubiorev.2020.03.005
dc.identifier.urihttps://hdl.handle.net/11454/62328
dc.identifier.volume113en_US
dc.identifier.wosWOS:000531531100004en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofNeuroscience and Biobehavioral Reviewsen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSchizophreniaen_US
dc.subjectBipolar disorderen_US
dc.subjectDNA methylationen_US
dc.subjectHistone modificationen_US
dc.subjectNon-coding RNAen_US
dc.titleThe clues in solving the mystery of major psychosis: the epigenetic basis of schizophrenia and bipolar disorderen_US
dc.typeReview Articleen_US

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