No pituitary gland volume change in medication-free depressed patients

Basit Öğe Kaydı
dc.contributor.authorEker C.
dc.contributor.authorOvali G.Y.
dc.contributor.authorOzan E.
dc.contributor.authorEker O.D.
dc.contributor.authorKitis O.
dc.contributor.authorCoburn K.
dc.contributor.authorGonul A.S.
dc.date.accessioned2019-10-26T23:56:29Z
dc.date.available2019-10-26T23:56:29Z
dc.date.issued2008
dc.departmentEge Üniversitesien_US
dc.description.abstractIncreased serum cortisol levels and a hyperactive hypothalamo-pituitary-adrenal (HPA) axis have been proposed to play an important role in the pathophysiology of Major Depressive Disorder (MDD). However, there are inconsistent results regarding pituitary gland volume (PGV), which is one of the key elements of the HPA axis evaluated by MRI in depressed patients. In this study, we analyzed the PGV of medication-free moderately depressed MDD patients (N = 34) and age and sex matched healthy controls (N = 39). PGV did not differ between MDD patients and healthy controls [mean volume ± S.D.; 0.76 ± 0.17 cm3 and 0.75 ± 0.14 cm3; ANCOVA, F1,69 = 1.25 p > 0.05; respectively]. Our results confirm that volumetric PGV changes are not crucial for depression pathophysiology among unmedicated, moderately depressed adults. © 2008 Elsevier Inc. All rights reserved.en_US
dc.description.sponsorshipThis study is a part of SoCAT Project supported by Ihsan Dogramaci Foundation and was partially supported by Huray Fidaner Research Award of Izmir Psychiatric Association to corresponding author (ASG). --en_US
dc.identifier.doi10.1016/j.pnpbp.2008.05.023en_US
dc.identifier.endpage1632en_US
dc.identifier.issn0278-5846
dc.identifier.issue7en_US
dc.identifier.pmid18573301en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage1628en_US
dc.identifier.urihttps://doi.org/10.1016/j.pnpbp.2008.05.023
dc.identifier.urihttps://hdl.handle.net/11454/20817
dc.identifier.volume32en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofProgress in Neuro-Psychopharmacology and Biological Psychiatryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHPA axisen_US
dc.subjectMajor depressionen_US
dc.subjectMood disordersen_US
dc.subjectMRIen_US
dc.subjectNeuroimagingen_US
dc.subjectPituitary glanden_US
dc.titleNo pituitary gland volume change in medication-free depressed patientsen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu