The effect of prolactin levels on MPV in women with PCOS

Basit Öğe Kaydı
dc.contributor.authorYilmaz, Ozgur
dc.contributor.authorCalan, Mehmet
dc.contributor.authorKume, Tuncay
dc.contributor.authorTemur, Muzaffer
dc.contributor.authorYesil, Pinar
dc.contributor.authorSenses, Mehmet Y.
dc.date.accessioned2019-10-27T22:27:09Z
dc.date.available2019-10-27T22:27:09Z
dc.date.issued2015
dc.departmentEge Üniversitesien_US
dc.description.abstractObjectivePolycystic ovary syndrome (PCOS) is associated with cardiovascular risk factors including hypertension, obesity, hyperlipidaemia and glucose intolerance. Several studies demonstrated the link between PCOS and an increased risk of cardiovascular disease. Platelets play a crucial role in the development of atherothrombotic disease. Mean platelet volume (MPV) is a marker of platelet size that reflects its activity. Research points to a link between prolactin (PRL) and platelet activation. The purpose of this study was to investigate whether prolactin levels are associated with MPV in women with PCOS. DesignThe research was designed as a cross-sectional study. PatientsParticipants were divided into three groups-PCOS patients with mildly elevated PRL levels (n=72), patients with PCOS with normal PRL levels (n=207) and healthy controls (n=90). They were body mass index and age-matched and consecutively recruited. MeasurementsComplete blood counts, serum glucose, prolactin, insulin, lipids, high-sensitivity C-reactive protein and free-testosterone levels were measured. ResultsAmong the three groups, MPV levels were higher in women with PCOS having mildly elevated PRL levels (P<0001) and MPV was found to be correlated with PRL levels (r=0387, P<0001). Multiple regression analysis showed that PRL levels were associated with MPV levels (R-2=0239, =0354, P<0001). ConclusionMean platelet volume levels are significantly increased in women with PCOS having mildly elevated PRL. Our results suggest that there is a link between prolactin and MPV levels. In women with PCOS, elevated PRL levels may increase the risk of developing atherothrombotic events via the activation of platelets.en_US
dc.identifier.doi10.1111/cen.12647en_US
dc.identifier.endpage752en_US
dc.identifier.issn0300-0664
dc.identifier.issn1365-2265
dc.identifier.issue5en_US
dc.identifier.pmid25359296en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage747en_US
dc.identifier.urihttps://doi.org/10.1111/cen.12647
dc.identifier.urihttps://hdl.handle.net/11454/50583
dc.identifier.volume82en_US
dc.identifier.wosWOS:000352717000017en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofClinical Endocrinologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleThe effect of prolactin levels on MPV in women with PCOSen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu