Up-regulation of serine/threonine protein phosphatase type 2A regulatory subunits during methylprednisolone-induced differentiation of leukaemic HL-60 cells
Küçük Resim Yok
Tarih
2000
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Blackwell Science Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Serine/threonine protein phosphatase 2A (PP2A) may play a role in leukaemic cell differentiation of the HL 60 myeloid leukaemic cell-line after methylprednisolone induction. We have investigated the specific enzyme activity and expression of catalytic and regulatory subunits of PP2A. The resulting specific enzyme activity and immunoblots showed an increase in enzyme activity and the expression of regulatory subunits after methylprednisolone treatment. There was no change in the expression of PP2A catalytic subunits. It is suggested that the effect of methylprednisolone on leukaemic differentiation may be the result of PP2A upregulation.
Açıklama
Anahtar Kelimeler
PP2A, methylprednisolone, HL-60 cells, leukaemia, differentiation
Kaynak
Clinical and Laboratory Haematology
WoS Q Değeri
Q4
Scopus Q Değeri
N/A
Cilt
22
Sayı
5
