Effect of gingival inflammation on the inflammatory response in patients with idiopathic uveitis

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dc.contributor.authorAkcali, Aliye
dc.contributor.authorYilmaz, Suzan Guven
dc.contributor.authorLappin, David F.
dc.contributor.authorEgrilmez, Sait
dc.contributor.authorBuduneli, Nurcan
dc.date.accessioned2019-10-27T23:09:05Z
dc.date.available2019-10-27T23:09:05Z
dc.date.issued2016
dc.departmentEge Üniversitesien_US
dc.description.abstractObjectivesThis study aimed to investigate the levels of 11 oral species in plaque samples and cytokine levels in biofluid samples of patients with idiopathic uveitis (IU) and systemically healthy individuals (H) with or without gingival inflammation. Material & MethodsTwenty-one patients with IU (n=21), and 22 systemically healthy individuals (n=22) were enrolled in the study. Clinical periodontal measurements were recorded. Cytokine levels in the biofluid samples were determined by ELISA. Bacterial gene copy numbers were determined by qPCR on plaque microbial DNA preparations. ResultsAccording to two-step cluster analysis, anova and t-test: GCF, serum and salivary TNF-, IL-17A, IL-17A/E; GCF and serum IL-6; salivary IL-17F, and salivary and serum IL-17A/F levels were higher in the IU group than the H group (p<0.05). However, serum IL-10 and IL-17E levels were higher in the H group than the IU group (p<0.05). A.actinomycetemcomitans, F.nucleatum, S.oralis, A.naeslundii, and V.dispar counts were higher in IU group compared to H group (p<0.05). ConclusionAltered local and systemic cytokine profiles are associated with differences in the microbial plaque composition in IU. Anti-inflammatory cytokines; IL-10, IL-17E are reduced in patients with IU and Th-1 and Th-17 driven inflammatory responses in biofluids are altered.en_US
dc.identifier.doi10.1111/jcpe.12555en_US
dc.identifier.endpage645en_US
dc.identifier.issn0303-6979
dc.identifier.issn1600-051X
dc.identifier.issue8en_US
dc.identifier.pmid27028890en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage637en_US
dc.identifier.urihttps://doi.org/10.1111/jcpe.12555
dc.identifier.urihttps://hdl.handle.net/11454/52507
dc.identifier.volume43en_US
dc.identifier.wosWOS:000380166000002en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Clinical Periodontologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectcytokine(s)en_US
dc.subjectdental plaqueen_US
dc.subjectgingivitisen_US
dc.subjectinterleukin(s)en_US
dc.subjectuveitisen_US
dc.titleEffect of gingival inflammation on the inflammatory response in patients with idiopathic uveitisen_US
dc.typeArticleen_US

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