The effect of immunosuppressive treatment on arterial stiffness and matrix Gla protein levels in renal transplant recipients

dc.contributor.authorGungor, O.
dc.contributor.authorKircelli, F.
dc.contributor.authorCarrero, J. J.
dc.contributor.authorHur, E.
dc.contributor.authorDemirci, M. S.
dc.contributor.authorAsci, G.
dc.contributor.authorToz, H.
dc.date.accessioned2019-10-27T21:24:10Z
dc.date.available2019-10-27T21:24:10Z
dc.date.issued2011
dc.departmentEge Üniversitesien_US
dc.description.abstractIntroduction: Arterial stiffness is a risk marker for cardiovascular events. In this study we aimed to compare the effect on calcineurin inhibitors (CNI) and mammalian Target of Rapamycine inhibitors (mTORi) on arterial stiffness in renal transplant patients. Patients and methods: 81 renal transplant patients under CNI-based or mTORi-based protocol for at least 6 months were included in the study. Arterial stiffness was measured by using the SphygmoCor device (AtCor Medical, Sydney, Australia). Vitamin K-dependent, calcification inhibitor matrix Gla protein (MGP) concentrations were quantified by ELISA methods (Biomedica, Vienna, Austria). Results: 34 patients were on mTORi-based and 47 on CNI-based immunosuppression. Mean age was 37.9 +/- 10.8 (18 - 71) years and 45% were female. Age, gender, graft functions and follow-up period of the groups were similar. Augmentation index was 15.2 +/- 12.6% in CNI and 18.8 +/- 14.0% in mTORi groups (p > 0.05). There was no difference regarding carotid-femoral pulse wave velocity between groups. Arterial stiffness was positively correlated with age, total cholesterol, LDL cholesterol, mean arterial pressure (MAP) and proteinuria. MGP levels were higher in the mTORi group but were not predictors for carotid-femoral pulse wave velocity. Conclusion: Rather than specific immunosuppressive drug effects, conventional risk factors, blood pressure and proteinuria are the most important predictors for arterial stiffness in renal transplant patients.en_US
dc.identifier.doi10.5414/CNP75491en_US
dc.identifier.endpage496en_US
dc.identifier.issn0301-0430
dc.identifier.issue6en_US
dc.identifier.pmid21612751en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage491en_US
dc.identifier.urihttps://doi.org/10.5414/CNP75491
dc.identifier.urihttps://hdl.handle.net/11454/44411
dc.identifier.volume75en_US
dc.identifier.wosWOS:000292063500002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherDustri-Verlag Dr Karl Feistleen_US
dc.relation.ispartofClinical Nephrologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectarterial stiffnessen_US
dc.subjectcalcineurin inhibitorsen_US
dc.subjectimmunosuppressive drugen_US
dc.subjectmTOR inhibitorsen_US
dc.subjectrenal transplantationen_US
dc.titleThe effect of immunosuppressive treatment on arterial stiffness and matrix Gla protein levels in renal transplant recipientsen_US
dc.typeArticleen_US

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